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Clin Path RBC 3

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britt611's version from 2017-01-18 05:19

Section 1

Question Answer
Anemia from reduced or ineffective erythropoiesis implies a lacking of... (4)1. normal stem, progenitor and precurser cells, 2. normal stimulating/growth factors, 3. normal nutrients (iron), 4. normal microenviornment - bone marrow
What type of anemia is associated with reduced or ineffective erythropoiesis?non- regenerative
What are 4 possible causes of Normocytic normochromic anemia with normal neutrophils and plts?1. lack of erythropoiein (chronic renal failure), 2. anemia of chronic inflammation or anemia of chronic disease, 3. FeLV- associated anemia, 4. Immune mediated directed against developing cells (PRCA- pure red cell aplasia
what are the indices for anemia of chronic inflammation / anemia of chronic diseaseNormocytic normochromic anemia with normal neutrophils and plts
What are the indices for lack of erythropoietin- chronic renal failure?Normocytic normochromic anemia with normal neutrophils and plts
what are the indices for FeLV associated anemia?Normocytic normochromic anemia with normal neutrophils and plts
what are the indices for immune mediated directed against developing cell - PRCANormocytic normochromic anemia with normal neutrophils and plts
What interleukon and other byproduct is associated with anemia of chronic inflammation/chronic disease?IL-6-- also increased production of hepcidin by liver- this decreased transport of iron and inability of bone marrow to respond to EPO
What are 2 anemia's we see with Normocytic, normochormic anemia with decreased neutrophils and platelets (pancytopenia)Aplasitc anemia and myelophthisic anemia
What are some possible causes for Aplastic anemia?Infectious (ehrlichia, felv, parvo, FIV, chronic EIA), drugs/toxins (estrogen, bracken fern, chromtherapies), irradation, idopathic
What is a possible cause of myelophthisic anemia?bone marrow is replaced by neoplastic cells or fibrosis
what type of indices do you see with aplastic and myelophthisic anemia? Normocytic, normochormic anemia with decreased neutrophils and platelets (pancytopenia
What are some causes of microcytic, hypochromic anemia with variable neutrophils and plts?#1 = iron deficiency anemia, anemia of chronic inflammation, portosystemic shunt, pyridoxine B6/Cu deficiency
Describe indicides and lab work of iron deficiency anemia?microcytic, hypochromic anemia with variable neutrophils and plts. Decrease in serum iron and ferritin, TIBC is normal to increased, sometimes thrombocytopenia
What are some causes of macrocytic normochromic anemia with variable neuts and pltsVit B12/folic acid deficiency, FeLV infection, erythroid neoplasia, inherited disorder in herefords
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Section 2

Question Answer
Define polycythemiaincrease in Hct, Hgb, RBC
What are the 2 types of polycythemia?relative and absolute
what are the 2 types of absolute polychythemiaPrimary and secondary
Describe the erython mass of relative polycythemiaerython mass is normal
what are causes of relative polycythemia dehydration and splenic contraction
Describe the erython mass of absolute polycythemiaincreased erython mass
What are the causes of absolute primary polycythemia vera?myeloproliferative disease - EPO is normal or decreased
What are the 2 types of secondary absolute polycythemiaappropriate and inappropriate
What causes appropriate secondary absolute polycythemiachronic hypoxia or pulmonary disease- increased EPO production
What are causes of inappropriate secondary absolute polycythemia?tumor production of EPO
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