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Clin path- Hematopoietic Neoplasia

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britt611's version from 2017-02-01 21:33

Section 1

Question Answer
What are 4 main types of hematopoietic neoplasialeukemia, lymphoma, multiple myeloma (plasma cell neoplasia), myeloproliferative diseae
What are the 2 general classificaitons?lymphoproliferative and myeloproliferative (non-lymphoid)
what are 3 examples of lymphoproliferative lymphoma, leukemia, plasma cell neoplasia (mulltiple myeloma)
where does lymphoma originate?solid tissues outside the bone marrow
where does lymphoid leukemias originatein the bone marrow, have acute and chronic types
where does myelo leukemia originatebone marrow - acute vs chronic
what are 2 examples of myeloprolifaterative diseaseleukemia and other myeloproliferative disorders
define acute leukemiasless differentiated, more immature
what are the 2 types of acute leukemiasacute lymphocytic leukemia and acute myeloid leukemia
define chronic leukemiamore differentiated, recognizable cells
which leukemia do you see a decrease in normal blood cellsacute leukemia
what type of cells are a good indication of leukemiablasts cells
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Section 2

Question Answer
explain the cells you would see in ALLlarge immature lymphoblast in bone marrow and peripheral blood- chomatin open, nucleoil is promient- counts in peripheral blood will be VERY hight- > 100,000
Define myeloproliferative diseaseany neoplasic disorder of non-lymphoid blood cells- can be acute, chronic with myelodysplastic syndroms
what does myeloproliferative diease includeall other WBC, RBC and plts
what is an example of myeloproliferative disease that is not a leukemiaerythremic myelosis (true erythroid leukemia)
what species is erythremic myelosis common in and what is it associated withcats and associated with FelV infection
what cells you do see with an erythremic myelosiscirculating abnormal erythroic cells (nRBC), oftern without reticulocytosis
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Section 3

Question Answer
What cells do you see with AMLblasts are large with immature open chromatin - may see some evidence of differetiation toward neutrophils monocytes and other lineage. increased peripheral blood can be very high >100,000/mlL
what do the cells look like in CLLlymphocytes smaller, well differentiated and mature,
What species is CLL most common indogs and humans
which leukemia is often an incidentally findingCLL
what lymphocytes are associated iwth CLLT cells
what must you distinguish from CLLreactive lymphocytosis at lower counts
what can CLL becomeblast crisis
describe the cells in chronic myeloid leukemia (CML)mature and easily recognizable- this is very rare in vet met - more likely to be sever inflammaotry or paraneoplastic neutrophilia
What are the morphologic abnormailites of myelodysplastic syndromes?in the blood cell seen in in BM
what can myelodysplastioc syndromes includenon-regenerative anemia, thrombocytopenia, neutropeina or combos
What else can myelodysplastic syndromes be calledpre-leukemias
what virus is also associated with myelodysplastic syndromes FeLV + cats are at higher risks
how do you differentiate lymphoma from ALLblast counts often higher in ALL, normal blood cell concentration decreased in ALL and ALL can spread to solid tissues, but often confined to marrow
when do you see lymphoma cells in circulation?stage V
What are some diagnostic tests for hematopoietic neoplasia?blood smears, BM examination
how do you confirm lymphoid neoplasiaPARR
What test is used to characterize neoplasiaimmunophenotyping for specific antibodies
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Section 4

Question Answer
Define clonalitiy testingtesting for clonalitly by PCR antigen receptor rearragnmentt
what are the test results on clonality testing for neoplasia and hyperplasianeoplasia = one band, hyperplasia = more then 1 band
what does flow cytometry test foridentifies cell types based on surface expression of antigens
what are granular lymphocytesCTLs or NK cells
describe lymphoma of granular lymphocytesoften more aggressive clinically
where does lymphoma of granular lymphocytes arise in the dog and catdog= spleen, liver cat = mostly GIT
what are 3 forms of plasma cell neoplasiaplasmacytoma, multiple myeloma, waldenstroms macroglobinurmia
what are plasmacytomatumors outside of the bone marrow
what are MMplasma cell neoplasia in multiple sites in the bone marrow- often includes production of excessive ammunoglobulins
what are key laboratory features of MManemia, pancytopenia, increase plasma cells in BM, serum hyperflobulinemia- monoclonal light chain
what is the criteria for diagnosis MMneed 3 of 4: 1. osteolytic bone lesion on imaging, 2. monoclonal gammopathy, 3. bence-jone proteinuria, 4. > 15-20% plasma cell in BM
What are some other common pathologic changes in MMhypercalcemia (ionized ca), renal disease (light chain--> azotemia), hyperviscoity syndrome and hemorrhagic diathesis
what is plasmacytomasolitary tumors (extramedullary plasmacytomas), con occur in the mouth skin or any internal organs
where do cats get plasmacytomaliver, spleen involvement with MM
dogs and plasmacytomaosseous plasmacytoma is rare- usually progress to MM over time
describe waldenstroms macroglobulinemiaplasma cell neoplasia that produced IgM- rare in vet met, bone marrow involvement similar to MM
describe mast cells in circluationusually do to inflammation, can be due to cell neoplasia- if it is you see increase % in WBC
What are 4 types of histiocytic neoplasiacutaneous histocytoma (non neoplastic), reactive histiocytosis (benign neoplasia), low grade mallicancy, malignant neoplasia
what are 2 types of histocytic neoplasia seen in dogscutaneous histocytoma, reactive histiocytesis
what histioctyic neoplasia do we see in catslow grade malignancy- feline progressive histiocytosis
histiocytic sarcoma- malignant neoplasia..occures in most sites, see in bernese, retrievers and roteweilers
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