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Cholinergics - Pharmacology Exam 1

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ewright2's version from 2016-09-06 14:32

Section

Question Answer
Atropine •Preanesthetic agent •Muscarinic antagonist
Glycopyrrolate •Preanesthetic agent •Used to treat bradycardia (don’t cross the BBB so less side effects) •Muscarinic Antagonist
Bethanechol•Mimics Ach •Used to assist bladder emptying in blocked cats • Increases GIT motility
Pirezepine •Treats ulcers •M1 selective – inhibits gastric secretions •Muscarinic antagonist
Scopolamine •Antiemetic (treats motion sickness) •Muscarinic Antagonist
Pilocarpine •Partial agonist •Used to constrict pupil in ophthalmology to manage glaucoma •M3~M1>M2
Tropicamide •Mydriasis for ophthalmology examinations •Muscarinic Antagonist
Edrophonium•Diagnose myasthenia gravis •Short acting AChE Inhibitor
Pralidoxime (2-PAM)•Antidote to nerve gas (Dyflos) o Only treats the neuromuscular effects, not muscarinic effects of organophosphates •Cholinesterase reactivation
Neostigmine •Intermediate acting AChE inhibitor •Prolong Ach action – anticholinesterase •Treatment for curare, reversal of nicotinic receptor neuromuscular blocking agents
Pridostigmine •Oral treatment for myasthenia gravis • Intermediate acting anticholinesterase •Treatment for curare
Ecothiopate •Glaucoma treatment •Irreversible AChE inhibitor (anticholinesterase)
Tubocurarine •Prototype N1 or Nn activity (ganglionic side effects) •Neuromuscular-blocking drug
Pancuronium•Long acting neuromuscular blocking drug, more potent than curare with less ganglionic side-effects
Succinylcholine•Short acting depolarizing blocker •Metabolized by BuChE in plasma •Used in the past for euthanasia in horses (inhumane) • Blockage intensified by AChE inhibitors
Nicotine •Nicotinic acetylcholine receptor (nAChR) agonist
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