Cholesterol lowering agents

jennifer12345's version from 2017-12-09 22:12

Section 1

Question Answer
Effects of statinsdecrease LDL, increase HDL, decrease triglycerides, decrease level of CRP
Effects of fibric acid derivativesuppress lipolysis in adipose tissue, decrease free fatty acid flux, lower rate triglyceride synthesis
Effects of bile acid sequestrantsdecreased LDL, increased triglycerides, no change in HDL
Effects of nicotinic aciddecreased triglycerides, increased HDL
Effects of selective cholesterol absorption inhibitordecreased LDL, decreased triglycerides, increased HDL

Section 2

Question Answer
Adverse effects of atorvastatin, lovastatin, fluvastatin, simvastatin, rosuvastatinfatigue, rash, cough, chest pain, abd pain, anemia, progression cataracts, gynecomastia, sun sensitivity, rhabdomyolysis, increased LFTs
Adverse effects of gemfibrozil, fenofibrate, lofibrahepatotoxicity, cholelithiasis, fatigue, rash, a fib, abd pain, rhabdomyolysis, increased glucose, N/V
Adverse effects of cholestyramine, colestipol, colesevelamfatigue, weight gain/loss, chest pain, HA, hematuria, constipation, abd pain, malabsorption medications/nutrients
Adverse effects of niacinhyperglycemia, hyperuricemia, arrythymias, GI upset, N/V, rhabdomyolysis, HA, hepatotoxicity, vision disturbances
Adverse effects of ezetimibe (zetia), vytorinfatigue, cough, abd pain, diarrhea, dizziness
Adverse effects of lovazaflu- like symptoms, dyspepsia, rash

Section 3

Question Answer
Mechanism of action: fibric acid derivativeincreased lipoprotein lipase activity, increased catabolism of VLDL
Mechanism of action: bile acid sequestrantsbind to bile acids and increase excretion, liver increases catabolism of LDL to cholesterol to make up for loss bile acids
Mechanism of action: nicotinic acid (niacin)inhibition of free fatty acid release from adipose tissue
Mechanism of action: statin (hmg-coA reductase inhibitor)inhibition of cholesterol synthesis by blocking enzyme hmg-coA reductase
Mechanism of action: selective cholesterol absorption inhibitorinhibit cholesterol from being absorbed from bile & diet into the intestine at the brush border
Mechanism of action: omega-3 acid ethyl ester (lovaza)decreased hepatic triglyceride synthesis

Section 4

Question Answer
Cautions with bile acid sequestrantscontraindicated in biliary obstruction, interferes with absorption of fat soluble vitamins
Cautions with niacingout, diabetes, liver disease, gallbladder disease
Cautions with selective cholesterol absorption inhibitorsnot recommended with hepatic insufficiency (pro-drug)
Cautions with lovazafish allergy