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Chemo

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vitohuxo's version from 2016-07-04 22:50

Section 1

Question Answer
adjuventtherapy given after primary therapy
neoadjuventtherapy given before primary therapy to shrink size of tumor
cisplatin** high emetic risk...nausea and vomiting, nephrotoxicity (max dose 100mg/m2 per cycle), neuropathy
doxorubicinnause and vomiting, cardiomyopathy= do not exceed lifetime recc cumulative dose of 450-550 mg/m2
epirubicinnausea and comiting
cyclophosphamidenausea and vomiting, hemorrhagic cystitis
ifosfamidenausea and vomiting, hemorrhagic cystitis
flourouracilmucositis, diarrhea
capecitabinemucositis, diarrhea
irinoticanmucositis, diarrhea
methotrexate mucositits, nephrotoxicity
vincristineconstipation
pomalidomideconstipation
thalidomideconstipation
qt prolongationtyrosine kinase inhibitors...(end in ib)
amifostine (ethyol) may be given with ___ to reduce renal damagecisplatin
mesna (mesnex) given with ____ to reduce risk hem cystitits ifosfamide
vincristineneuropahty....limit dose to 2mg per week
vinblastineneuropathy
vinorelbineneuropathy
oxaliplatinneuropathy
paclitaxelneuropathy
docetaxelneuropathy
cabazitaxelneuropathy
leuvocovin given with ___ to increase efficacyflourouracil
atropine given with ___ to help diarrheairinotecan
leucovorin given with _________ to reduce myelosupression and mucosititsmethotrexate
glucarpidase given with ___ in acute renal failure/high concmethotrexate
nadirthe lowest point that WBCs and platelets reach occurs about 7-14 days after chemotherapy, generally recover about 3-4 weeks post treatment
neutropeniaANC is below 1000 cells/mm3
severe neutropeniaanc below 500 cells/mm3
profound neutropeniaANC below 100 cells/mm3
lomustine oral cancer drug mod to high emetic risk
memorize

Section 2

Question Answer
filgrastimneupogen,zarxio. myeloid growth factor prevent neutropenia
pegfilgrastimneulasta. myeloid growth factor prevent neutropenia
sargramoastinleukine. myeloid growth factor prevent neutropenia
highly emotogenic chemo regimen/dosing acute:NKa-RA + steroid + serotonin antag OR olanzapine + steroid + serotonin antagonist
highly emetogenic chemo regimen dosing delayed:nk1-ra + steroid
aprepitantemend- NK1-RA given 3 days
fosaprepitantemend iv- NK1-RA given 1 day
dexamethasonesterioid given 4 days
dolasetronanzemet - serotonin antag given day 1..oral
granisetronkytril- serotonin antag....oral, iv, or patch
ondansetronzofran- serotonin antag...oral or iv
palonosetronaloxil - serontonin antag...oral or iv
olanzapine regimenolanzapine 4 days, dexamethasone 1 day, palonosetron day 1
prochlorperazinecompazine- dopamin antag for breakthrough nausea
promethazinephenergan- dopamine antag for nausea
metoclopramidereglan- dopamine antag for nausea
rolapitantvarubi- NK1-RA given 1 day
calcitoninmiacalcin- hypercalcemia
zoledronic acidzometa- hypercalcemia
denosumabxgeva- hypercalcemia
memorize