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Chemo drugs MOA

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mblackamp0513's version from 2017-04-27 13:22

Section

Question Answer
CyclophosphamideNonspecific cell target, strong electronegative reaction, acrolein, excreted via bladder
MethotrexateInhibits DHFR. Folate antagonists kill cells in the S phase
5-FlurouracilUracil replaced with fluorine. Drug incorporated into DNA, imbalance
LeucovorinPreferentially saves normal cells in opposition to cancer cells
VincristineCell cycle specific. Disruption of microtubules kills cells during metaphase (M phase)
EtoposideInhibits DNA gyrase. G2 arrest
DoxorubicinIntercalation with DNA during uncoiling. S phase toxicity. Topisomerase inhibitor
Cisplatinenters cells via diffusion. N7 gunina reactive site
Imatinib mesylateOral tyrosine kinase inhibitor, targets philadelphia chromosome
TrastuzumabHuman epidermal growth factor receptor 2, monoclonal Ab helps with tumor regression
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