Chemo drugs 1A

britt611's version from 2017-01-18 04:58

Section 1

Question Answer
what are 2 examples of platinum agents1. Carboplatin, 2. Cisplatin
Carboplatin covalently binds to...DNA interstrands (90%) and intrastrends (10%)
what is carboplatin metabolized by?metabolized by reaction with H2O and binding to plasma proteins
where/how is carboplatin excreted?70% unchanged via urine
What does carboplatin have a strong correlation with?carboplatin exposure and renal function (renal malfunction results in increased toxicity)
Does carboplatin cause nephrotoxicity?NO!
Describe the NADIR of carboplatinlong biphasic NADIR (7 and 21 days)
What are the clinical uses of carboplatin?osteosarcoma (#1), anal sac adenocarcinoma, transitional cell carcinoma
What is the dose limiting toxicity of carboplatinbone marrow suppression
What animal should you never use cisplatin in?CATS
Why should diuresis be performs before and after cisplatin administration?can cause severe renal toxicity
how is cisplatin excreted?renal excretion - 50% unchanged
What is the clinical use of cisplain?osetosarcoma

Section 2

Question Answer
What are 3 examples of antitumor antibiotics?Doxorubicin, mitoxantrone, actinomycine D
What are the microbial fermentation byproducts of antitumor antibiotics?anthracyclines, mitomycins and actinomycins
Why are syntheic forms made?to reduce toxicity
How is Doxorubicin (adriamycin) givenIV over 20 min or more
What is the mechanism of action of Doxorubicin (adriamycin)DNA intercalcation, inhibition of DNA and RNA polymerase, inhibition of topoisomerase II (!), DNA alkylation (!), induction of oxygen reactive speceis (!), inhibition of thioredoxin reductase
What is the dose limiting toxicities of Doxorubicin (adriamycin)1. hypersensitivity (diphenhydramine), 2. bone marrow suppression, 3. GI toxicity (metronidazole, cerina), 4. Dose related cardiotoxicity, 5. nephrotoxic -cats (tubular damage)
How is Doxorubicin (adriamycin) eliminated?liver (mostly) and kidney
Why is there long infusion times with Doxorubicin (adriamycin)decrease toxicity and increase drug efficacy
What is the clinical use of Doxorubicin (adriamycin)EVERYTHING
What is Dexrazoxane -Zinecard?potent intracellular cheating agent- chelates irion and reduced the amount of free radicals, Used in cases of doxorubicin EXTRAVASATION!
how much Dexrazoxane -Zinecard do you give when you suspect doxorubicin extravasation?10x the extravasated dose
Mitoxsantrone is a synthetic analog of?doxorubicin
What is the mechanism of action of MitoxsantroneDNA intercalation, inhibition of DNA and RNBA polymerase, inhibition of topoisomerase II, DNA alkyation, dose NOT induce oxygen reactive species
how is Mitoxantrone excreted?via urine and feces (30% unchanged)
What is the dose limiting toxicity of MitoxantroneGI and myelosuppression
What is the clinical use of MitoxsantroneTransitional cell carcinoma, lymphoma rescue, carcinomas
how is Actinomycin D given? IV
How is Actinomycin D absorbed?by passive diffusion to cells
what is the mechanism of action of Actinomycin Dintacts with single and double stranded DNA
How is Actinomycin D secreted?by urine (20% uncharged) and feces (15% unchanged)
what is the dose limiting toxicity of Actinomycin DGI, myelosuppression, can cause damage on extravasation, NOT cardiotoxic
What is the clinical use of Actinomycin Dlymphoma
What are 4 drug resistance mechanism of antitumor antibiotics?increase efflux MDR1 (pgp), increase antioxidant enzyme (GST,SOD), increasing DNA repair, increase drug conjugation (GST)

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