Cell Wall Synthesis Inhibitors

venomape's version from 2016-03-03 06:38


Question Answer
Transpeptidase is inhibited by what antibiotic ?penicillin and cephalosorins
What crosslink enzyme cross link cell wall together?Transpeptidase
Penicillins cause bacteria to form this shapespheroplast


Question Answer
The breakdown of pencillins by the penicillinase will produce what?penicilloic acids
Increase circulation of penicilloic acid will result in production of what?Antibody
Anaphylactic shock can occur as a result of penicilloic acid bind to what protein?albumin
What prolong half life of all penicllins?Probenicid
Pencillins can enter into the CSF in what case?Inflamed meninges
Changes to what protein can result in resistance to even B-lactamse resistant pencillinPBP


Question Answer
Gram+ non-β-lactamase producing streptococcuspenicillin G
Diphtheria, syphilispenicillin G
Gram+ non-β-lactamase producing staphylococcus aureusoxacillin
Skin infectionoxacillin
E. coli and community-acquired Gram-ampicillin/amoxicillin
Sinusitis, Otitis Media, Urinary Tract Infectionsampicillin/amoxicillin
Nosocomial-acquired infections, bacteremia, pneumoniatricarcillin/piperacillin
Gram- Enteric bacteria and Pseudomonastricarcillin/piperacillin
Bacterial resistance to tricarcillin/piperacillin, ampicillin/amoxicillin, oxacillin, penicillin GB-lactamase
β-lactam antibiotic hypersensitivitypenicillin G, oxacillin, ampicillin/amoxicillin, tricarcillin/piperacillin
Inhibits syn of peptidase bindingpenicillin G, oxacillin, ampicillin/amoxicillin, tricarcillin/piperacillin


Question Answer
Cell wall synthesis inhibitor bind peptidaseCefazolin-1, Ceftriaxone-3, Ceftazidime-3, Cefepime-4
β-lactam antibiotic hypersensitivityCefazolin-1, Ceftriaxone-3, Ceftazidime-3, Cefepime-4
Gram+ Strep/StaphCefazolin-1
Surgical prophylaxis and skin infections (cellulitis)Cefazolin-1
Broad spectrumCeftriaxone-3
Gonorrhea, meningitis, pneumoniaCeftriaxone-3
Broad spectrumCeftazidime-3
Pseudomonas bestCeftazidime-3
Broad spectrum and multi-drug resistant G-Cefepime-4
Pseudomonas and other nosocomial G- infectionsCefepime-4
Nonconvulsive status epilepticus-adjust dose in renal impairedCefepime-4


Question Answer
Cell wall synthesis inhibitor bind peptidaseImipenem/Meropenem, Aztreonam
very broad spectrum Gram- rods (pseudomonas), Gram+ and anaerobesImipenem/Meropenem
nosocomial drug-resistant and mixed infectionsImipenem/Meropenem
β-lactam antibiotic hypersensitivityImipenem/Meropenem
Can cause seizures, need cilastatin to block dihydropeptidasesImipenem
Gram - only, Primary use for P. aeruginosaAztreonam
Nosocomial acquired pseudomonal infectionAztreonam
Seizures and leukopeniaAztreonam
Tolerable to penicillin-sensitive patients, no cross-allergic reactionsAztreonam


Question Answer
Clavulanate, tazobactam, sulbactam added with what to broaden spectrum for anaerobic infection?penicillin
Community-acquired upper respiratory infections, sinusitis, otitis media(Augmentin) amoxicillin/clavulanate
Nosocomial infections covers Gram - pseudomonas(Timentin) Ticarcillin/clavulanate
Nosocomial infections, Gram-, Gram+, anaerobes in intra-abdominal infections, pseudomonas, pneumonia and sepsis, ICU for empiric treatmentZosyn - Piperacillin/tazobactam
Gram + coverage Staph/Strep cellulitis(Unasyn) ampicillin/sulbactam
Cell wall synthesis inhibitor bind peptidase substrate D-alanyl-D-alanine terminus siteVancomycin
Resistance to alteration to D-alanyl-D-serine terminus siteVancomycin
Gram+ broad spectrum, MRSA, penicillin-resistant strep and enterococcusVancomycin
nosocomial-acquired G+ serious iInfections ex. Osteomyelitis, endocarditis, line infectionsVancomycin
Effects-Redman’s Syndrome, Nephrotoxicity and ototoxicityVancomycin