CC Sept 2015 Serogroup B Meningococcal Vaccine

echoecho's version from 2016-04-26 03:20

Section 1

Question Answer
Meningococcal disease is caused by what bacteria?Neisseria meningitidis
Meningococcal disease can presents as what 3 conditions?1) meningitis (50.2%) 2) bacteremia (37.5%) 3) bacteremic pneumonia (9.2%)
Why has the incidence of disease been decreasing in the US?due to the introduction of routine immunization of adolescents in 2005
Despite of the declining incidence of cases (0.3 cases / 100,000) and despite appropriate antibiotics, the disease has a mortality of ___ to ___%? With ___ to ___% of survivors sufferring long term sequelae (neurologic deficits, hearing loss, limb or digit loss, intellectuall impairment)?10-15%; 11-19%
The vast majority of cases (98%) are _____, although outbreaks do occur?sporadic
List the 3 incidence peaks of meningococcal disease?1) infants and children < 5 years of age 2) adolescents 16-21 years of age 3) adults > 65 years of age
List the 5 serogroups of meningococcal disease? Which ones cause the majority of the disease?1) A, B, C, W, Y 2)with serogroups B, C and Y causing the majority of the disease)
Each of the above types acounts for about _____ of these cases?1/3
In children < 5 years of age, 60% of disease is caused by serogroup _____, with serogroups ____ and ____ accounting for most of the remaining cases?B; C & Y
In those > 11 years of age, serogroups ___, ____, and _____ cause 73% of the disease?C,W, Y
Routine immunization of adolescents is with one of the conjugated quadrivalent vaccines that containe serogroups ____, ____, ____ and ____?A, C, Y,W
List the 2 vaccinations used?1) Menactra 2) Menevo
What vaccine is used for those > 56 years of age for travel or during an outbreak?Menomune (MPSV4)
What vaccine is used for high-risk chileren 6 weeks to 18 months of age and contains serogroups C and Y, as well as H. influenaze vaccine?Bivalent HibMenCY-TT (MenHibrix)
In 2014, the FDA approved what vaccine?Trumenba (a 3 dose given at 0, 2, 6 month)serogroup B vaccine
In Jan 2015, the FDA approved what vaccine?Bexero (2 dose) given at least 1 month apart serogroup B vaccine (the same vaccine should be used to complete the series
What is the most common adverse reactions noted after administration?1) injection site pain 2) myalgias 3) fatigue 4) headache
A very small number of serious adverse effects were noted, but all resolved without sequelae, name these?1) seizure 2) hypersensitivity reaction
*** The Advisory Committee on Immunization Practices (ACIP) has released recommendations regarding the use of these 2 new vaccines. List them?Individuals > 10 years of age with the following risk fxs are vaccine candidates: 1) persons with persistent complement component deficiencies (including inherted or chronic deficiencies in C3, C5-9, properdin, factor D or factor H) or patients taking eculizumab (Soliris) 2) persons w/ anatomic or functional asplenia (including sickle cell disease) 3) microbiologists routinely exposed to isolates of Neisseria meningitidis 4) persons identified at increased risk becasue of a serogroup B meiningococcal disease outbreak
List other inidividuals who are at increased risk NOT included in the above recommendations?1) children 2 months to 9 year of age 2) travelers to endemic areas (becasue disease in these countries is usually not serotype B) 3) first-year college students living in residence halls 4) military recruits.
While it would be optimal to immunize young children who are at high risk for meningococcal serotype B disease, why has it been difficult to develop a vaccine that produces sufficient antibodies in this population, even with conjugation to a carrier protein?because of the structure of the serotype B meningococcus
It is hoped that with new vaccine ______, effective vaccination of young children will be possible?technologies
*** SUMMARY = Two new vaccines are available, one is a ____-dose and the other is a _____ dose?2; 3
*** SUMMARY = It is indicated for some patients at elevated risk > ____ years of age?10
*** SUMMARY = Most common adverse effects are what?1) injection site pain 2) myalgias 3) fatigue 4) headache

Section 2