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CC Nov 2016 Hyperparathyroidism in CKD

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echoecho's version from 2017-01-15 19:19

Section

Question Answer
What abnormality is a common complication of CKD?Electrolyte
The kidney serves a central role in ____ and ____ regulation through conversion of 25-hydroxy vitamin D to 1,25-dihydroxy vitamin D?Calcium; phosphorus
1, 25-dihydrox vitamin D promotes absorption of dietary _____ from the GI tract?calcium
In patients with CKD (regardless of the etiology), the loss of functioning kidney tissue results in a decrease in the enzyme ___________ that is responsible for conversion of vitamin D to the active form?alpha-1-hydroxylase
In addition, levels of ___________ increase in patients with CKD also reducing levels of 1, 25-dihydropyridine vitamin D?fibroblast growth factor 23 (FGF-23)
As vitamin D levels and serum calcium derived from GI source decreases, what hormone is released?PTH (parathyroid hormone)
What does PTH stimulated?the mobilization of calcium from skeletal sources to normalize serum calcium
Because the other portion of the normal feedback loop, the activation of vitamin D, is unable to occur in the diseased kidney, the parathyroid glands are forced to produce PTH leading to what?1) hypertrophy of the glands 2) chronic hypocalcemia 3) hyperphosphatemia
What do chronic hypocalcemia and hyperphosphatemia cause?secondary hyperparathryoidism
memorize
What is CKD mineral bone disorder (CKD-MBD)?