CC Nov 2015 HPV-related cancer

echoecho's version from 2015-12-09 13:34


Question Answer
HPV includes > ____ DNA virus types that infect human epithelial cells and have been implicated in the development of what cancers? 1) cervical 2) anogenital 3) oropharyngeal squamous cell cancers
HPV can be divided into what categories?1) high-risk 2) low-risk
List the high-risk types of HPV?1) HPV -16 2) HPV-18
List the low-risk types of HPV?those associated with warts
HPV is the most common sexually transmitted infections in what gender? Although the majority of patients who are infected are _______ (asymptomatic vs. symptomatic)?1) women 2) asymptomatic
After infection with HPV, up to 90% of women with cervical HPV infection will clear the infection within ____ years?2
The peak incidence of infection in women occurs int he early portion of the ____ decade of life?third
Pathophysiology of high-risk HPV?1) high-risk HPV integrates its viral DNA into the epithelial cells DNA 2) this produces oncoproteins that degrade tumor suppression genes
70% of HPV-related cervical cancer is due to HPV ___ and HPV ____?16; 18
Co-infection with multiple high-risk types increases what risk?carcinogensis
What is the usual interval between infection and dx of CA?10-20 years
CIN 1 (cervical intraepithelial neoplasia) is an active HPV infection that requires follow-up with what procedure?colonoscopy
CIN 2 and CIN 3 shows to be considered ____-risk lesions?high
Website for guidelines of management of cervical cytological abnormalities?
How many FDA-approved HPV vaccines are available for prevention of HPV infection and HPV-associated cancer?two
List the 2 vaccines?1) Cervarix 2) Gardasil
Cervarix covers ____ HPV subtypes?2
Gardasil covers ____ HPV subtypes?9
Cervarix and Gardasil are a 3-shot series approved for women and are to ____% effective at preventing > CIN2 lesions?96%
Website for vaccination facts?
Gardasil is also approved for use in MALES ages ___ to ___ for prevention of genital warts and anal dysplasia/cancer?9; 26
HPV is also associated with oropharyngeal cancers. Prevalence increased by ____% between 1998 and 2004?225%
About ___% of these newly diagnosed oropharyngeal cancers are due to HPV?75%
It is estimated that by 2020 the number of HPV-positive oropharyngeal cancers may be greater than the number of cases of _____ cancer?cervical
HPV-positive oropharyngeal cancer differs from HPV-negative oropharyngeal cancers which are typically attributable to _____ and ____ abuse?tobacco and/or alcohol abuse
*** List the characteristics of HPV-positive oropharyngeal cancers?1) associated with a younger age at dx 2) oral sexual behavior 3) a better overall survival 4) a better response to the treatment
What 2 substance abuses are associated with an increased risk of developing cancer?1) tobacco 2) marijuana
What is the most commonly implicated serotype of HPV, accounting for 88% of cases?HPV 16
List the most common presenting symptoms in a retrospective study of 400 patients with percentages?1) neck mass (55%) 2) sore throat (33%) 3) dysphagia (16%)
Comment on the screening tests for oropharyngeal cancers due to HPV?there are none
What is the gold standard for diagnosis for oropharyngeal cancers due to HPV?biopsy of suspicious lesions
Localized lesions can be treated how?1) by excision 2) possible radiation 3) chemotherapy for extensive disease
Have the effects of HPV vaccines on the development of HPV-positive oropharyngeal cancers been studied?no
However, in a randomized trial of young women in Costa Rica, what was the conclusion regarding HPV-16/18 vaccine in comparison to its effectiveness in preventing infection in oropharyngeal vs cervical cancer?more effective in preventing oropharyngeal infection (93%) vs cervical infection (72%)
*** SUMMARY = After infection with HPV, up to 90% of women with cervical HPV infection will clear the infection in ____ years?2
*** SUMMARY = 70% of HPV-related cervical cancer is due to HPV____ and HPV ____?16; 18
*** SUMMARY = Approximately ___% of these newly diagnosed oropharyngeal cancers are due to HPV?75
*** SUMMARY = Regarding oropharyngeal HPV cancers, patients are _____ (older vs. younger) than patients with HPV-negative tumors and have overall _______(worse vs. better) survival?younger; better