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CC July 2016 Multitarget Fecal DNA Test for colorectal cancer screening

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echoecho's version from 2016-11-25 23:35

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Question Answer
Worldwide, colorectal canc (CRC) is the ____ most common cancer in women and the ______in men?third; fourth
What does screening for CRC and precancerous lesions does what?reduces cancer risk and identifies earlier stage cancers that are more amendable to treatment
Cancer screening for patients at average risk for CRC begins at age _____ years and continues to age ____ years?50; 75
It may be offered until age ____ based on individual assessment?85
Patients at higher risk (those with a first degree relative who developed CRC before 50 years) should begin screening ____ years prior to th age CRC was diagnosed in their first-degree relative?10
Despite the effectiveness of CRC screening, what percent of the eligible population snot undergone screening?35%
A umber if methods are available for screening, name these?flex sig, fecal occult blood testing, computed tomography (virtual colonoscopy) and colonoscopy
Which of the above methods is considered the gold standard and why is it not desirable to patients?colonoscopy; may not be readily available to patients and requires a thorough bowel prep prior to the procedure.
In 2014 the FDA approved the first multitarget fecal DNA test called _____ for CRC?Cologuard
What does the Cologuard detect?It detects fecal occult blood and both aberrantly methylated DNA (NDRG4 and BMP3) and DNA mutations (KRAS) associated with precancerous and cancerous colorectal lesions.
Sensitivity is less tha with what methods of screening, but more than what method of testing?colonoscopy; fecal occult blood testing
Sensitivity for detecting advanced precancerous lesions is _____% compared to fecal immunochemical test (FIT) which is _____%?42%; 24%
False positive rate is _____%?13%
Does sensitivity vary between male and female patients?no
What is the collection procedure like?one stool sample collected at home and mailed to a processing lab
Multitarget fecal DNA testing is currently recommended every ____ years for cancer screening in an average risk patient aged 50 years and older; this interval may change as future research provides evolving information on optimal screening intervals?3
*** positive Multitarget DNA test results mandate follow-up what?colonoscopy
What screening methods is the method of choice for patients at high risk for CRC?colonoscopy
Does the USPSTF recommend multitarget DNA testing as a screening method for CRC, although the test is gaining increasing acceptance as an alternative to what screening method?no; colonoscopy
Cologuard is expensive and is covered by Medicare every ____ years and reimbursement fee is $______?3; 502
*** SUMMARY = What does Cologuard detect?1) fecal occult blood 2) aberrantly methylated DNA (NDRG4 and BMP3) and DNA mutations (KRAS) associated with precancerous and cancerous colorectal lesions
*** SUMMARY = What is the recommended testing interval?3 years
*** SUMMARY = Does the USPSTF recommend multitarget DNA testing as a screening method for CRC, although the test is gaining acceptance as an alternative to colonoscopy screening?no
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