CC Jan 2016 Systolic Blood Pressure Intervention Trial (SPRINT)

echoecho's version from 2015-12-30 10:01


Question Answer
Why was the trial stopped early?due to the marked reduction in cardiovascular events associated with lowering the SBP to <120 mm Hg
What 2014 recommendations are in conflict with SPRINT?8th Joint National Committee (JNC-8) particularly in regards to older individuals
*** SPRINT found a ______% relative risk reduction for cardiovascular events like CVA, MI, heart failure) and a _____% relative risk reduction for death in the 120 mm Hg systolic group compared to the 140 mm Hg systolic group?30; 25
What was the algorithm for medication in the 120 mm Hg group?initiation of two or three drug therapy with thiazides diuretics and or angiotensin converting enzyme (ACE) inhibitors or angiotensin receptor blockers and or calcium channel blockers
When were beta blockers and other agents used?If there was a compelling reason
What was the average number of medications in the 140 mm Hg group? In the 120 mm Hg group?two; three
While the results are compelling, concerns have been raised, true or false?true
*** SPRINT study was stopped early, why?because of the dramatic reduction in death in those treated to a systolic BP of 120 mmHg, true or false?true
*** The National Instutes of Health has been critized, why?because they announced the positive results but no safety data.