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CancerAgentsClasses

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wasabi's version from 2015-04-15 15:51

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Question Answer
uses mesnacyclophosphamide and ifosfamide (alkylating)
oxidation activatesalkylating
lomustinealklating. nitrosurea
carmustinealkylating. nitrosurea
cyclpopshamidealkylating. mustard
mechlorethamine hclalkylating. mustard
ifosfamidealkylating. mustard
MAOIprocarbazine
temozolomidetriazene alkylating
chlorambucilalkylating. mustard
dacarbazineakylating. triazene
bendamustineaklylating. mustard
streptozocinalkylating. nitrosurea
hydrolysis activatesplatinum
amifostine used forcisplatin. reduces renal toxicity
oxaliplaitnplatinum agent. cross link. neuropathy
cisplatinplatinum. cross link
carboplatinplatinum. cross link. thrombocytopenia
methotrexatefolate antimetabolite.
pemetrexedfolate anitmetabolite
folate antimetabolites do what?s phase spec. dihydro reducaste inhib
leucovorin used to decrease toxicitymethotrexate
pyrimidine anti inhibitthimidylate synthase
leucovorin admin with to increase activity offlourouracil (concurrently)
floxuridinepyrimidine anti. rapidly converted to FU
cepecitabinepyrimidine anti
cytarabinepyrimidine anti
gemicitabinepyrimidine anti
flourouracilpyrimidine anti
kcat inhibpyrimidine (flourouracil)
glucarpidase inactivatesmercaptopurine
azathioprinepurine. prodrug of mercaptopurine
nelarabinepurine
mercaptopurinepurine. inhibits de novo purine synthesis
pentostatinpurine. inhibits adenosine deaminase
fludarabine phosphatepurine. antimetabolite due to arabinose & 2-Fl
clofarabinepurine. 2-Cl is resistant to deaminase by adeosine deaminase
nelarabinepurine. 6-methoxy is water soluble (10X)
hydroyxureapurine. inhibs ribonucleotide reductase
cladribinepurine
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