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Calcium Channel Blockers

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turlough's version from 2017-10-30 13:40

Section 1

Question Answer
2 amlodipine formulationsTablets and oral solution
Contents of Acerycal Amlodipine and perindopril
Contents of CoverdineAmlodipine, perindopril and indapamide
Contents of Exforge Amlodipine and valsartan
Contents of Exforge HCT Amlodipine, Valsartan and hydrochlorothiazide
Contents of Konverge Amlodipine and olmesartan
Contents of Konverge PlusAmlodipine, Olmesartan and Hydrochlorothiazide
Contents of Twynsta Amlodipine and telmisartan
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Section 2

Question Answer
3 licensed indications of amlodipine 1) Hypertension. 2) Chronic stable angina pectoris. 3) Prinzmetal's angina a.k.a. variant angina.
Typical dose of amlodipine Start at 5 mg once daily. Increase to a max of 10 mg daily.
When might it be advisable to start with a lower dose of 2.5 mg od? Hepatic impairment
What drugs may amlodipine be used in combination with in the treatment of hypertension? ACE inhibitors, Angiotensin Receptor Blockers, thiazide diuretics, beta blockers and alpha blockers.
5 contra-indications to the use of amlodipine 1) Hypersensitivity to amlodipine or other dihydropyridines. 2) Severe hypotension. 3) Obstruction of the outflow tract of the left ventricle (e.g. high grade aortic stenosis). 4) Unstable heart failure post-MI. 5) Pregnancy
Does food affect amlodipine absorption? No
Amlodipine is a major substrate of which enzyme?CYP3A4/5
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Section 3

Question Answer
5 interactions with amlodipine 1) Anti-hypertensives. 2) NSAIDs. 3) Simvastatin 4) CYP3A4/5 inducers. 5) CYP3A4/5 inhibitors.
Explain the interaction between amlodipine and NSAIDsNSAIDs reduce the efficacy of amlodipine.
Explain the interaction between amlodipine and simvastatin and how it should be managedAmlodipine increases the risk of simvastatin's side effects. Patients on amlodipine should take no more than 20 mg of simvastatin daily
2 very common side effects of amlodipine Peripheral oedema and pulmonary oedema
5 common side effects of amlodipine Headache, dizziness, flushing, abdominal pain and constipation,
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Section 4

Question Answer
How to monitor efficacy of amlodipine when using it for hypertensionReduction in blood pressure
How to monitor efficacy of amlodipine when using it for anginaReduced chest pain and frequency of angina attacks and in use of nitroglycerin pump spray.
3 counselling points for amlodipine 1) Avoid driving or operating machinery until you know how the drug affects you as it can cause dizziness. 2) Avoid alcohol. 3) Avoid stopping the drug suddenly due to the risk of rebound hypertension/angina. 4) Report side effects such as oedema or signs of liver dysfunction.
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