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Breast Cancer Histology

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Updated 2007-03-10 07:59

Breast Cancer Histology

Typical characteristics of various breast cancers

 

DiagnosisDescription
Intraductal carcinoma of the breastTumor cells fill ducts, tumor cell necrosis results in cheese-like consistency
Invasive ductal carcinomaMost common type, characterized by tumor cells arranged in cords, islands, and glands embedded in a dense fibrous stroma; abundant fibrous tissue results in firm consistency
Paget disease of breastEczematoid lesion of the nipple or areola; neoplastic Paget cells, characteristic large cells surrounded by a clear halo-like area, invade the epidermis; underlying ductal carcinoma almost always present
Lobular carcinoma in situClusters of neoplastic cells fill intralobular ductules and acini; may lead to invasive carcinoma many years later (in the same or contralateral breast); often bilateral at the time of diagnosis
Medullary carcinomaCellular with scant stroma; soft, fleshy consistency; characteristic lymphocytic infiltrate, prognosis better than that for invasive ductal carcinoma
Mucinous carcinomaPools of extracellular mucus surrounding clusters of tumor cells; gelatinous consistency; prognosis better than for invasive ductal carcinoma
Inflammatory carcinomasLymphatic involvement of skin by underlying carcinoma, causing red, swollen, hot skin resembling an inflammatory process; peau d'orange, poor prognosis
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