Breast cancer and other path

veranellasel's version from 2015-06-27 16:39

Section 1

Question Answer
invasive ductal carcinoma has 4 types1. tubular carcioma, mucinous carcinoma, medullary carcinoma, inflammatory carcinoma
mucinous carcinomacarcinoma w/ abudant extra cellular mucin; good prognosis
tubular carcinomawell differentiated tubules that lack myoepithelial cells
BRCA1 carriersmedullary carcinoma
high grade cells growing in sheets w/ lymphocytes and plasma cellsmedullary carcinoma
inflamed swollen breast that doesn't respond to antibioticsinflammatory carcinoma
why does inflammatory carcinoma have the worst prognosis?carcinoma is in dermal lymphatics and so can be spread
mistaken for acute mastitisinflammatory carcinoma
prognosis for tubular and mucinousgenerally pretty good
Paget's DxDCIS that extends up the ducts to involve the skin
nipple ulceration and erythemaPagets of Breast
duct like structures in a desmoplastic stromainvasive ductal carcinoma

Section 2

Question Answer
mammary duct ectasiainflammation of dilation of subareolar ducts
green brown nipple discharge (inflammatory debris)mammary duct ectasia
fibrocystic change fibrosis and cysts in breast
sclerosing adenosisincreased number of glands at end in lobule (see calcifications)
atypical hyperplasiaincreased number of cells in ductal lining or in glands


Question Answer
can fibrocystic change turn into breast cancerno. benign but fibrocystic related changes can be increase breast cancer risk
does sclerosing adenosis increase breast cancer risk?yes. by 2X
does atypical hyperplasia increase breast cancer risk?yes by 5X
who gets mammary duct ectasia?50-60s y old women
most common change in premenopausal breast and driven by hormonesfibrocystic change of breast

Section 3

Question Answer
intraductual papillomapapillary growth in to a large duct; see epithelial and myoepithelial cells
difference between papillary breast cancer and intraductal papilloma?papillary carcinoma has no myoepithelial cells; may see bloody nipple discharge
who gets papillary carcinoma? young or oldpost menopausal women
fibroadenoma tumor of fibrous tissue and glands
most common benign neoplasm of breastfibroadenoma
who gets fibroadenoma?younger women
well circumscribed mobile marble like massfibroadenoma
are fibroadenoma estrogen sensitive?yes; grow and shrink in pregnancy and menstration
Phyllodes tumorfibroadenoma like tumor w/ overgrowth of fibrous component
leaf-like projections in biopsyphyllodes tumor
can phyllodes tumors become malignant?yes;
who gets phyllodes tumors? young or old?post menopausal
estrogen sensitive benign tumors:fibrocystic change and fibroadenoma
benign tumors of younger womenfibrocystic change and fibroadenoma
benign tumors of older women?phyllodes tumors, intraductal papilloma