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Bone Tumors Clinical Features

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fuckdaveliu's version from 2018-05-18 19:55

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Question Answer
OsteomaArises on the surface of facial bones and associated with Gardner syndrome
Osteoid OsteomaOccurs in young adults <25 years of age, arises in cortex of long bones, presents as bone pain that resolves with aspirin, Imaging reveals a bone mass <2 can with a radiolucent core (osteoid)
OsteoblastomaLarger >2cm, arises in vertebrae, and presents as bone pain that does not respond to aspirin
OsteochondromaArises from a lateral projection of the growth plate(metaphysis); bone is continuous with the marrow space, overlying cartilage can transform(rarely) to chondrosarcoma
OsteosarcomaPeak incidence in teenager and less commonly seen in elderly, risk factors include familial retinoblastoma, Paget's Disease, and radiation exposture. Arises in the metaphysis of long bones, usually the distal femur or proximal tibia(region of the knee). Presents as a pathological fracture or bone pain with swelling. Imaging reveals a destructive mass with a 'sunburst' appearance and lifting of the periosteum(Codman triangle). Biopsy reveals pleomorphic cells that produce osteoid
Giant Cell TumorOccurs in youn adults. Arises in the epiphysis of long bones, usually distal femur or proximal tibia. 'Soap Bubble' appearance on x-ray. Aggressive tumor and may recur
Ewing SarcomaArises in the diaphysis of long bones; usually in male children (<15 yrs old). 'Onion skin' appearance on x-ray. Biopsy reveals small, round blue cells that resembles lymphocytes(can be confused with lymphoma or chronic osteomyelitis) with 11;22 translocation. Often presents with metastasis, responsive to chemotherapy
ChondromaArises in the medulla of small bones of the hands and feet
ChondrosarcomaArises in medulla of the pelvis or central skeleton
Metastatic tumorsOsteolytic punched-out lesions, except in prostatic carcinoma it classically produces osteoblastic lesions
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