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Block 9 Virus

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klau253's version from 2017-06-02 17:49

Section

Question Answer
Icosahedralcan be enveloped or naked
Helicalenveloped only
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Question Answer
Enveloped DNAonly Herpes, hep B, Poxvirus (everything else naked)
All RNA viruses are enveloped exceptPicornavirus (Hep A), Calcivirus (Norovirus), Reovirus (Rotavirus)
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Question Answer
-ve RNA virusmainly helical except Reovirus
-ve RNA virusBunnies myxed with Rhadbies orthought to Fight in Delta Arena (Bunyairus, paramyxo, Rhado, orthomyxo, filo, delta, arena)
+ve RNA virusmainly icosahedral except corona
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Question Answer
Naked virusrotavirus, norovirus
Enveloped virusHIV, Ebola, influenza
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-ve strand ss RNA virus
Question Answer
envelopedall of them
Capsidto help with replication
Exinfluenza, mumps, measles, rabies, Ebola
entire life cycle isextra-nuclear
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+ve strand ss RNA/Ds RNA virus
Question Answer
Capsidto help with replication
Entire life cycleextra-nuclear
Ex of +ve SS RNApoliovirus, dengue, hep C
Ex of Ds RNA virusrotaviruses (most common cause of diarrhoea among infants and children)
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Retrovirus
Question Answer
requiresreverse transcriptase
Viral genomeintegrates into host cell chromosomal DNA
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Ex. HIV

 

Hepadnaviridae Family
Question Answer
Exhep B
FeatureDNA genome and use reverse transcriptase
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DNA virus
Question Answer
Featureintranuclear assembly of virus, released by cell lysis
Exherpes, Epstein Barr, adenovirus
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HIV complications
Question Answer
CD4 <200oesophageal candidiasis, pneumocystic pneumonia(jirovecii)
CD4 <100cytomegalovirus, mycobacterium avium intracellulare
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HIV treatment
Question Answer
Nucleoside RT inhibitors (NRTI)ends with DINE, BINE, SINE except abacavir and tenofovir (zidovudine)
Non-nucleoside RT inhibitors (NNRTIs)-vir- in the middle
Protease inhibitor-navir at the end (amprenavir)
Integrase inhibitor-vir at the end/ -teg- in the middle
CCR5 inhibitorMaraviroc
Boosting agentsRitonavir, cobicistat
Typical antiretroviral therapy2 NRTIs + 1 either NNRTI/PI/II
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Question Answer
Herpes labialisaka cold sores, remain as latent in trigeminal ganglion, more common in HSV-1
Herpes whitlowlesion on finger/skin, dentist at risk
Herpes neonatorumvertical transmission of HSV
Varicella/chickenpoxinitial infection with varicellar zoster virus
Herpes zostershingles, by dermatomes
acycloviractivated by viral thymidine kinase to inhibit viral DNA polymerase
Amantadineinhibits viral H+ channel (M2 channel)
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