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Block 9 Parasites

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klau253's version from 2017-04-21 18:40

Section

Malaria
Question Answer
CausesPlasmodium falciparum/vivax/ovale/malariae
Tertian fevervivax/ ovale/ falciparum
Quartan fevermalaraie
complicationscerebral malaria, metabolic acidosis causing resp distress, severe anaemia
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chemotherapy of malaria
Question Answer
quinolinesHaem polymerase inhibitor Ex. Quinine
antifolatesinhibits dihydrofolate reductase Ex. Pyrimethamine
Artemisinin compoundsinteraction of the peroxide-containing drug with heme in the parasite food vacuole(results in toxic radicals) Ex. Artemether
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African Trypanosomiasis
Question Answer
TransmissionTsetse flies
CausesTrypanosoma brucei rhodesiense/gambiense
Chemotherapypentamidine, suramin, melarsoprol, elfornithine, nifurtimox
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South American Trypanosomiasis (Chagas disease)
Question Answer
Transmissionblood-sucking triatomine insects, congenital, blood, feces contam
CauseTrypanosoma cruzi
complicationcardiac, digestive, neurological disorders
TxBenznidazole, Nifurtimox
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Leishmaniasis
Question Answer
transmissionsandflies (inject promastigotes which is phagocytosed by macrophages and converted to amastigotes)
TxPentavalent antimony (Pentostam, Glucantime), Amphotericin B, Miletfosine
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Toxoplasmosis
Question Answer
CauseToxoplasma gondii
Complicationscongenital toxoplasmosis (abortion, hydrocephalus)
TxPyrimethamine + sulfadiazine
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