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Block 9 Fungi

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klau253's version from 2017-06-02 20:21

Section

Types of fungi
Question Answer
Moldsasexual/sexual reproduction, Ex. Aspergillus
Yeastreproduce via budding, Ex. Candida, Cryptococcus neoformans
Dimorphiccan be either molds or yeast Ex. Coccidiodes
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Clinical manifestation
Superficial mycoses
Question Answer
no tissue invaded & no cellular response from hostTinea versicolor caused by Malasezzia furfur
No tissue invaded but host response eliciteddermatophytosis (ringworm/tinea)
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Deep/Systemic mycoses
Question Answer
commonest organismAspergillus fumigatus, results in pulmonary aspergillosis
Aspergillomacolonisation of a pre-existing lung cavity
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Question Answer
Invasive YeastCandida
Normal floramouth, lower female genital tract
manifestationOesophagitis, Candidaemia
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Dermatophytoses
Question Answer
Geophiliccontact with soil
Zoophiliccontact with animals Ex. Microsporum canis/gypseum
Anthropophiliccontact with humans, the only fungi which require humans for survival Ex. Trichophyton rubrum, Epidermophytan floccosum
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Antifungal drugs
Mucormycosis do not respond well to any antifungals
Question Answer
Amphotericinbinds to ergosterol to cause leakage of ions, resistance: Candida Lusitaniae, SE: nephro
Azolesinhibits lanosterol demethylase to interrupt ergosterol biosynthesis, SE: hepato, Candida resistance getting more common
Echinocandinsinhibits glucan synthase, indicated for invasive aspergillosis and candidal infections, resistance: Cryptococci, Dermatophytes
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