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Block 11 Teratology

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klau253's version from 2017-05-19 20:57

Causes of birth defects

Question Answer
risk of congenital malformation in young fit mother2-3%
drugs and chemicals account for ?% of birth defects4-6%
Major cause of birth defectidiopathic
spontaneous occurrence of spina bifida1:1000
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pharmacokinetic changes in pregnancy
Question Answer
Maternal metabolismincrease
maternal excretionincrease due to increase renal blood flow
Volume of distributionincrease
Body H2Oincrease
lung functionincrease
GI motilitydecrease
Albumindecrease
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Question Answer
period of maximal susceptibility to teratogenic effectsfirst 10 wk post-conception (2-9 week)
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Drugs asso/ with fetotoxic effects DURING T1
Question Answer
androgensvirilisation of female foetus
oestrogenfeminisation of male foetus
Warfarinnasal hypoplasia, skeletal defects
RetinoidsCraniofacial, CVS and CNS
Diethylstilboestroluterine lesions, transplacental carcinogen
Antiepilepticsfacial defects, mental retardation, neural tube
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Drugs asso/ with fetotoxicity AFTER T1
Question Answer
Antiepilepticsmental retardation, autism
NarcoticsResp depress
Warfarinfetal haemorrhage, CNS
antidepressatnswithdrawal
Benzoresp depress, withdrawal, floppy infant
ACEIoligohydraminous, growth retard, kidney hypoplasia, hypocalvaria, convulsion, hypotension, anuria
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