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Block 11 Breast Changes

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klau253's version from 2017-05-19 16:55

Breast changes in pregnancy

definition

Question Answer
Alveolisecretory units at the termini of ductules
Lactocytessecretory epithelial cells, line alveoli
Myoepithelial cellscontract to eject milk into ductules
Nipple poreseach breast has 10 duct openings
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endocrine influence in pregnancy

Question Answer
Oestrogenstimulate ductal system proliferation
Progesteronelobes, lobules and alveoli growth
Prolactinnipple growth, lobular development
Serum prolactin lactogenareola growth
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Lactogenesis

Question Answer
Stage 1from late pregnancy to 24-48 hrs after birth
Stage 2from 60 hrs postpartum to day 3
Stage 3from days 8 postpartum to beginning of involution
Involutionloss of secretory function of milk, appx 40 days after last breastfeeding
Triggered byprolactin, drop in progesterone and oestrogen
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Milk production in lactogenesis II and III

Question Answer
Prolactin receptor theoryfrequent suckling in early postnatal weeks increase prolactin receptors in alveoli --> therefore increase milk production
Feedback inhibitor of lactationslow milk synthesis when breasts are full
Prolactin inhibitory factorwhen breast is not emptied, hypothalamic factor increase to inhibit prolactin from ant. pit.
Milk ejection reflexoxytocin from post. pit. causes contraction of myoepithelial cells, milk then enters the ducts
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Question Answer
conditions that affect ability to breastfeedthyroid disorder, breast surgery, polycystic ovaries, low Hb, retained placenta
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