Bipolar disorder

kms013's version from 2016-01-28 02:28


Question Answer
What is bipolar disorder?A mental disorder characterized by cyclical shifts between manic and depressive episodes. It's very hard to diagnose, often misdiagnosed.
Characteristics of manic bipolarExcess euphoric feeling, irritable, agitated, decreased sleep, unrealistic beliefs in one's abilities and powers, distractibility, poor judgment, impulsivity, increased high risk or pleasurable activities, denial that anything is wrong
Depressive episodes includeLoss of interest in all activity, decreased energy, feelings of guilt and worthlessness, difficulty concentrating, sleep disturbances, change in appetite and activity level, chronic pain, thoughts of death
Two most common diagnosesType 1 & Type 2
Type 1Manic or mixed episodes that last at least 7 days, or manic symptoms severe enough to require hospitalization; depressive episodes usually last 2 weeks
Type 2Pattern of depressive and hypomanic episodes, not full blown manic
What is the largest component of bipolar?Genetics, evidence indicates transmission of the disease is X linked; possibly chromosome 18 or 21, but not proven
Some studies of identical twins as high as:80%
Bipolar disorder phenome databaseAllows scientists to link visible signs of bipolar with genes likely to cause them
Manic episodes are linked to increased levels of:Dopamine and norepinephrine
What is a mood stabilizer?Lithium prophylaxis
Onset of BD happens at what age?20's
During manic episodes 3 genes of _____were found to be higher in those with BD.Mitochondrial complex 1 (CSF levels also higher)
What is found in BD that is also a risk factor for schizophrenia?Psychosis risk allele

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