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Biopharmaceutics

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allelipraise's version from 2017-09-28 03:14

Section 1

Question Answer
BiopharmaceuticsStudy of the interrelationship of the physical and chemical properties of the drug, the dosage form (drug product) in which the drug is given, and the route of administration on the rate and extent of systemic drug absorption.
PharmacokineticsStudy and characterization of the time course (kinetics) of drug liberation, absorption, distribution, metabolism and excretion
LADMEdescribes the disposition of a pharmaceutical compound within an organism.
Liberationthe release of the drug from it's dosage form
Absorptionthe process of a substance entering the body
Distributionis the dispersion of substance throughout the fluids and tissues of the body
Metabolismirreversible transformation of parent compounds intro daughter metabolites
Excretionelimination of the substance from the body
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Section 2

Question Answer
Pharmacodynamicsthe study of the biochemical and physiological effects of the drugs on the body or within the body and the mechanism of drug action and the relationship between drug conc. and effect
BioavailabilityThe extent of drug absorption
Bioavailable doseThe fraction of an administered dose of a particular drug that reaches the systematic circulation intact
Pharmacogenetics study of inherited genetic differences in drug metabolic pathways which can affect individual responses to drugs, both in terms of therapeutic effect as well as adverse effects
PHARMACOGENOMICSstudy of how genes affect a person's response to drugs
PHARMACOTHERAPEUTICSstudy of the therapeutic uses and effects of drugs
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Section 3

Question Answer
Plasma Drug Conc-Time curveGenerated by measuring the drug concentration in plasma samples taken at various time intervals after a drug product is administered.
Minimum effective concentration (MEC)The minimum concentration of drug needed at the receptors to produce the desired pharmacologic effect.
Minimum toxic concentration (MTC)The drug concentration needed to just produce a toxic effect.
Onset timeThe time required for the drug to reach the MEC.
Duration of actionThe difference between the onset time and the time for the drug to decline back to the MEC.
The time of peak plasma levelThe time of maximum drug concentration in the plasma and is proportional to the rate of drug absorption.
The peak plasma levelThe maximum drug concentration, usually related to the dose and the rate constants for absorption and elimination of the drug.
Area under the curveIt is related to the amount of drug absorbed systemically.
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Section 4

Question Answer
Pharmacological testing– relationship between drug concentration and activity
Toxicological testing– Relation of tissue accumulation and toxicity
Dosage Regimen Design– dose and dosing interval – maximum therapeutic effect with minimal toxicity
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