B lactam and B lactamase inhibitor combinations

shevyatiwari's version from 2015-04-18 08:49


Question Answer
B lactamase enzymes reversibly hydrolyse amide bond of B lactam ringF, irreversibly
B lactamase is produced by ribosomesF, by chromosomal or plasmid genes. These can be transferred between bacterial organisms
B lactamase inhibitors inhibit B lactamase produced by enterobacteriacae, S aureus, GN anaerobesT
B lactamase inhibitors possess antibacterial activity on their ownF
B lactamase inhibitors inhibit chromosomal mediated B lactamaseF, plasmid mediated
B lactamase inhibitors inhibit B lactamase from Pseudomonas, enterobacter and citrobacterF, no activity against these
Clavulanate with Amoxycillin is poorly absorbedF, rapid absorption
Clavulanate with Amoxycillin peaks in 40-60 minutesT
Clavulantae with Amoxycillin should be taken fastingF, doesn't make a difference if with food or not
Ticar/Clav, Pip/Tazo are given IVT
Amp/Sul is given IMT
Renal impairment does not alter PKF, prolongs half life and -> increase in blood levels
Most common S/E are GIT
There are no advantages to giving Amox/Clav orallyF, reduces diarrhoea
Hyperesensitivity is equal to that of individual b lactamsT
Ticarcillin and piperacillin cause increased bleeding times and platelet aggregation dysfunctionT
Hyponatremia can be seen with Ticarcillin and PiperacillinF, hypernatremia
Transient elevation of transaminases, positive Coomb's, thrombocytopenia, neutropenia, eosinophilia are possible S/ET
Cholestatic injury is more common in Amox/Clav than amox aloneT
Sulbactam causes painT
Probenicid -> increased renal excretionF, delays renal excretion of the b lactam agent

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