Create
Learn
Share

Autoimmune for RA

rename
sgthuan's version from 2017-07-07 03:49

Non-Biologic Disease Modifying Anti Rheumatic Drugs DMARD - Avoid in pregnancy

genericbranddrug pearl
methotrexateOtrexup & Rasuvo (SQ qw),Trexall, Rheumatrex (t)max 20-25mg once per week, Warning - HEPATOTOXICITY, *** Folate supp - 5mg qw or 1mg qd, ** do NOT take with alcohol, SQ injection liquid should be Yellow
hydroxychloroquinePlaquenil+/- MTX, RETINOPATHY, eye exams q3m, take with food, *** replace MTX if hepatotoxicity
sulfasalazineAzulfidine+/- MTX, *** sulfa or salicylate allergy, take with food and full glass of water to avoid crystalluria, folate deficiency - folate 1mg qd, Warning skin rash SJS/TEN, G6DP deficiency, *** Yellow-Orange urine/skin DISCOLORATION
leflunomideArava+/- MTX, ***CI in pregnancy --> wait at least 2 years or accelerated drug elimination - cholestyramine 8g TID x 11d
tofacitinibXeljanz, Xeljanz XR (t)+/- MTX, 5mg BID, inhibit Janus Kinase (JAK) enzymes, do NOT use with biologics DMARD
memorize

Biologic Disease Modifying Anti Rheumatic Drugs DMARD - do NOT use with other biological DMARD or LIVE VACCINES

genericbrandclassdrug pearl
etanerceptEnbrel (SQ)TNF-alpha inhibitor+/- MTX, 50mg SQ qw, TB test, requires refrigeration, OK at room temp for 14 days
adalimumabHumira (SQ)TNF-alpha inhibitor+/- MTX, 40mg SQ qow, TB test, requires refrigeration, OK at room temp for 14 days
infliximabRemicade (IV ONLY)TNF-alpha inhibitor+ MTX, *** requires a FILTER and STABLE ONLY with NS, infusion rxn - premed with steroids, antihistamine, APAP
certolizumabCimzia (SQ)TNF-alpha inhibitor+/- MTX, 200mg SW qow, refrigerated!!!
golimumabSimponi (SQ&IV)TNF-alpha inhibitor+ MTX, 50mg SQ qMONTH ***, IV available and requires a FILTER
rituximabRituxan (IV ONLY)non-TNF, deplete CD20 B cells+ MTX, infusion rxn - premed with steroids, antihistamine, APAP, ** do NOT Shake
anakinraKineret (SQ)non-TNF, IL-1 receptor antagonist100mg SQ qd, *** give ONLY after failure of DMARDs, injection site rxn, ** Keep Refridgerated
abataceptOrencia (SQ&IV)non-TNF, selective T cells costimulator*** STABLE ONLY with NS, requires FILTER and Refrigeration
tocilizumabActemra (SQ&IV)non-TNF, IL-6 receptor antagonist+/- MTX, 162mg SQ qow (<100kg)
memorize

Recent badges