Atypical Antipsychotics

turlough's version from 2017-10-30 15:31

Section 1

Question Answer
What is the brand name of aripiprazole?Abilify
3 formulations of aripiprazole Tablets, oral solution and suspension for intramuscular injection
3 indications of aripiprazole Schizophrenia, bipolar disorder and depression
Explain the mechanism of aripiprazole
Does food affect the absorption of aripiprazole? No

Section 2

Question Answer
Aripiprazole is a major substrate of which hepatic enzymes?CYP2D6 and CYP3A4/5
Explain the relevance of pharmacogenetics to aripiprazole Patients who have a particular isoform of CYP2D6 are poor metabolisers of aripiprazole and thus are at greater risk of side effects.
Give three reasons for reducing the dose of aripiprazole1) CYP2D6 poor metabolisers. 2) Patient is on a CYP2D6 inhibitor. 3) Patients is on a CYP3A4/5 inhibitor.
5 interactions with aripiprazole 1) CYP3A4 inducers. 2) CYP3A4 inhibitors. 3) CYP2D6 inhibitors (e,g, quinidine, fluoxetine and paroxetine). 4) Serotonergic medicines (e.g. SSRIs and SNRIs). 5) Medicines known to cause QT prolongation
10 common side effects of aripiprazole Weight gain, anxiety, akathisia, tremor, dyskinesia, sedation, dizziness, headache, dry mouth and erectile dysfunction.

Section 3

Question Answer
How would you monitor the efficacy of aripiprazole? Monitor improvements in mental status
Mention one test that is important to carry out in certain patients taking aripiprazole. Patients at risk of diabetes mellitus should have their fasting blood glucose levels measured regularly.
Patients with a history of what condition should exercise extra caution when using aripiprazole and why?Seizures. Aripiprazole lowers the seizure threshold.
3 counselling points for aripiprazole 1) Avoid driving or operating machinery until you know how the drug affects you as it can cause sedation and dizziness. 2) Avoid alcohol. 3) Don't suddenly stop taking aripiprazole.