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Asthma

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wuriluxi's version from 2017-11-12 20:06

Section 1

Question Answer
beta 1 receptorsincreased rate & force cardiac contraction, increased renin excretion kidney
beta 2 receptorsconstriction vascular, coronary arteriole, uterine & skeletal smooth muscle, bronchial dilation, increased gluconeogenesis in liver
corticosteroids mechanism of actionsuppress cytokine production, airway eosinophil recruitment, release inflammatory mediators
anticholinergics mechanism of actionantagonism muscarinic receptors: reduces production cGMP results in bronchodilation
leukotriene modifiers mechanism of actioncompetitive leukotriene receptor antagonism causing decrease in bronchospasm
methylxanthines mechanism of actioninhibition of phosphodiesterase, leads to smooth muscle relaxation
IgE inhibitor mechanism of actioninhibition of IgE attachments to mast cells and basophils which decreases mediator release
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Section 2

Question Answer
beta 2 agonists are indicated for quick relief of symptomsTrue
corticosteroids do not need to be used continuously to maintain their effectFalse
mast cell stabilizers are used to help with inflammatory release in addition to LABA and inhaled corticosteriodTrue
anticholinergics are a good single agent for bronchospasmFalse
montelukast is preferred for use over zafirlukast in liver diseaseTrue
theophylline is preferred since it does not require drug level monitoringFalse
omalizumab (xoliar) is a good choice for allergic triggers of asthmaTrue
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Section 3

Question Answer
Adverse effects of beta 2 agoniststachycardia, htn, cough, nausea/vomiting, arrhythmias, tremor, dizziness, bronchospasm
Cautions for use of beta 2 agonistsCV disease, diabetes, hyperthyroidism, seizure disorder
Adverse effects of inhaled corticosteroidsoral fungal infections, oral laryngeal/pharyngeal irritation, cough, respiratory infection
Adverse effects of oral corticosteroidsmoon facies, weight gain, edema, infection, suppression of hyper pituitary axis
Adverse effects of mast cell stabilizersheadache, nausea, cough, rhinitis, dizziness, bad taste, bronchospasm, eosinophilic pna
Adverse effects of anticholinergicsheadache, dizziness, palpitations, dry mouth, constipation, urinary retention, worsening of glaucoma
Adverse effects of leukotriene modifiers fever, rash, anaphylaxis, dyspepsia, increased LFTs, headache, dizziness
Adverse effects of methylxanthinesfever, rash, tachypnea, tachycardia, arrhythmias, hypotension, nausea/vomiting, seizures
Cautions for use of methylxanthinesheart disease, seizure disorder, peptic ulcer disease, liver and renal disease, arrhythmias
Adverse effects of IgE Inhibitorsmalignancy, anaphylaxis, injection site reactions, viral infections, arthralgia, pain, fatigue, dizziness
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Section 4

Question Answer
Examples of beta 2 agonists- short actingalbuterol, levalbuterol, pirbuterol, terbutaline, metaproterenol, isoproterenol
Examples of beta 2 agonists- long actingsalmeterol, formoterol, arformoterol
Examples of corticosteriodsprednisone, prednisolone, methylprednisolone, beclomethasone, mometasone, ciclesonide
Examples of LABA and inhaled corticosteroidsalmeterol and fluticasone (advair), budesonide and formoterol (symbicort)
Examples of mast cell stabilizerscromolyn, nedocromil, pemirolast, lodoxamide, ketotifen
Examples of anticholinergicsipratroprium (atrovent), tiotropium (spiriva)
Examples of leukotriene modifierszafirlukast, montelukast
Examples of methylxanthinestheophylline, aminophylline
Examples of IgE inhibitorsomalizumab (xoliar)
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