Aromatase Inhibitors

turlough's version from 2017-10-30 14:51


Question Answer
What class does anastrozole belong to? Aromatase Inhibitors
What is the brand name of anastrozole? Arimidex
What is anastrozole licensed for? Treatment of estrogen receptor-positive breast cancer in post-menopausal women
How does anastrozole work? Anastrozole inhibits the conversion of androgens (specifically androstenedione) to estrogens (specifically estrone) by the aromatase enzyme. The reduced levels of circulating oestrogen remove the tumour's growth stimulus.
Why is anastrozole only licensed in post-menopausal women? Anastrozole is only effective in post-menopausal women because in these women, the main source of oestrogen is that produced from androstenedione by the aromatase enzyme. In pre-menopausal women, oestrogen is mainly produced by the ovaries and anastrozole has no effect on this source.
3 contraindications to aromatase Hypersensitivity. Pregnancy. Breastfeeding.
Does food affect the absorption of anastrozole? No
2 interactions with anastrozole Tamoxifen and oestrogen-containing therapies will reduce the efficacy of anastrozole.
6 very common side effects of anastrozole Headache, hot flushes, nausea, rash, joint pain and osteoporosis.
Explain why anastrozole is associated with an increased risk of osteoporosis Aromatase reduces the levels of oestrogen. This removes the inhibitory effect that oestrogen has on osteoclasts. Thus, bone resorption increases.

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