AP concentrations, diseases, pathways, adrenergic

catgoesmoo's version from 2017-01-17 12:42

Section 1

Question Answer
142 extracellular 10 intracellularNa+
4 extracellular 140 intracellularK+
2.4 extracellular 0.0001 intracellularCa+
12 extracellular 58 intracellularMg+
103 extracellular 4 intracellularCl-

Section 2

Question Answer
autoimmune CNS--demyelinating disease that also damages CNS axonsmultiple sclerosis
autoimmune PNS--leads to muscle weakness and paralysisguillain-barre syndrome
pre-synaptic autoimmune disease seen in pts w/ lung cancer--antibodies to Ca+ channel leads to muscle weaknesseaton lambert syndrome
post-synaptic autoimmune disease results in antibodies against nicotinic receptors--facial and muscle weaknessmyasthenia gravis
worst form of muscular dystrophy--dystophin is absent and usually fatal by age 30 b/c of resp. failureduchennes muscular dystrophy
form of muscular dystrophy--less terrible b/c dystrophin is present but in altered or reduced amounts--slow progressive weakness of lower limbs and pelvisbecker muscular dystrophy
least terrible form of muscular dystrophy--mutations of sarcoglycan genes or other dystrophin components--progressive muscle wastinglimb-girdle
neurodegenerative disease that results in progressive loss of voluntary movement--muscles atrophy and become scleroticamyotrophic lateral sclerosis
potentially fatal response to anesthesia--results from ryanodine (Ca+) channel mutationsmalignant hyperthermia

Section 3

Question Answer
Gq-->PLC-->PIP2-->IP3 and DAG-->increased Ca2+ and PKC a1 M1 M3
Gs-->adenylyl cyclase-->ATP-->cAMP-->PKA upB1 B2 D1
Gi-->adenylyl cyclase-->cAMP down-->PKA downa2 M2 D2

Section 4

Question Answer
blocks tyrosine hydroxylasemetyrosine
rate limiting enzyme catecholamine synthesistyrosine hydroxylase
transports dopamine into synaptic vesicleVMAT
blocks VMAT transporterreserpine
transports synthesized catecholamines into vesiclesVAMP
inhibits VAMPbretylium
transports NE back into pre-synaptic terminal after releaseNET1