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Antivirals

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roshanbagga's version from 2017-08-08 22:41

Section

Question Answer
Neuraminidase inhibitorsused for flu, prevents viral release and causes aggregates to clump at cell surface (they can't bud off)
Interferonsstimulate uninfected cells to produce antiviral proteins
Adamantanes - Amantadineused for flu, inhibits uncoating by blocking M2 channels from letting H+ into virion, prevents RNA release
Integrase strand transfer inhibitors INSTIsfor HIV, stops viral DNA from combining with host DNA
Reverse transcriptase inhibitorsfor HIV, inhibit replication of viral genome - NRTIs and NtRTIs incorporate into DNA and cause chain termination (need phosphorylation to triphosphate form to activate)
Acyclovir ACVfor HSV, needs viral thymidine kinase to become activated and start phosphorylation to triphosphate only works on infected cell
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