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Antivirals

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renasshini's version from 2017-12-03 18:07

Section 1

Question Answer
Anti-HIV drug classes Nucleoside and nucleotide reverse transciptase inhibitors (NRTIs)
Nonnucleoside reverse transciptase inhibitors (NNRTIs)
Protease Inhibitors
Integrase inhibitors
Fusion inhibitors
memorize

Section 2

Question Answer
NRTIs MOAphosphorylated to active drug
inhibit viral reverse transciptase (cause chain temination and prevents replication)
NNRTIs MOAinhibition of DNA polymerase
different binding site than NRTIs
doesn't require phosphorylation
Protease inhibitors MOAinhibits protease enzyme responsible for cleaving Gag-Pol polyprotein
immature viron is noninfectious
Integrase inhibitors binds integrase- enzyme essential for incoporation into the host cell genome
inhibitors of viral replication
Fusion inhibitors blocks HIV attachment and enty by inhibitoring gp41-mediated fusion or CCR5-mediated fusion
inhibitors of viral attachment and entry
memorize