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Antiretroviral Drugs

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turlough's version from 2017-10-30 18:02

Section 1

Question Answer
What is the brand name of atazanavir? Reyataz
What class does atazanavir belong to? HIV Protease Inhibitors
What is atazanavir licensed for? Treatment of HIV-1 infections
Is atazanavir used as monotherapy? No, it is used in combination with one or more other antiretrovirals.
What drug is typically used in combination with atazanavir? Ritonavir
How should atazanavir be taken? Atazanavir should be taken with a large meal as food increases its absorption.
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Section 2

Question Answer
Discuss atazanavir in the context of hepatic enzymes. Atazanavir is metabolised by CYP3A4/5 and is a strong inhibitor of this enzyme.
What medicines are contra-indicated in combination with atazanavir?Simvastatin, rifampicin, sildenafil, St John's Wort and medicines that are substrates of CYP3A4 and have narrow therapeutic windows (e.g. alfuzosin, ergot alkaloids, terfenadine, triazolam and oral midazolam).
What must be considered in terms of interactions with treatment involving atazanavir? Not only does atazanavir have many interactions, the drugs that it is used in combination with (e.g. ritonavir) will also have interactions that must be taken into account.
6 common side effects of atazanavirFatigue, rash, headache, nausea, vomiting and diarrhoea.
3 counselling points for atazanavir 1) Swallow capsules whole with food. 2) Don't start any new medicines without talking to your doctor or pharmacist. 3) Use contraception as antiretrovirals don't prevent transmission of HIV.
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Section 3

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Section 5

Section 6

Section 7

Section 8

Section 9

Section 10