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Antiprotozoal, malarial, helminthic

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roshanbagga's version from 2017-08-08 22:57

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Question Answer
Metronidazoleantiprotozoal (Giardia, Trichomoniasis Vaginalis), needs flavodoxin for uptake (found only in anaerobes) - inhibits DNA replication
Pentamidinetargets DHFR, inhibits folic acid synthesis (thus DNA synthesis)
Quinines e.g. Chloroquinineantimalarial, interferes with hematin detoxification - blood schizontocide stage
Doxycyclineantimalarial, protein synthesis inhibitor 70s ribosomes, interferes with apicoplast (biosynthetic pathways) - blood and liver stage
Artemisininantimalarial, releases free-radicals into parasite vacuoles, damaging membranes - inhibits metabolism e.g. glycolysis - ACT
Nitazoxanideantihelminthic, inhibits anaerobic metabolism - targets pyruvate ferredoxin oxidoreductase
Ivermectinantihelminthic, inhibits neural and neuromuscular transmission - targets chloride channels
Thiabendazoleantihelminthic, immobilisation - targets B-tubulin
Praziquantelantihelminthic, uncontrolled calcium entry causing paralysis - targets Ca2+ transportation across tegument
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