| Drug (memorize) | Mechinism (memorize) |
|---|
| fosfomycin | inactivates phosphoenol pyruvate, halts muramic acid synth |
| isoniazid echinocandins | cell wall synth inhibitor |
| azoles | inhibit ergosterol synth by inhibiting lanosterol demethylase |
| triazole: fluconazole, itraconazole | can use systemically |
| allylamines: terbinafine | topical and systemic |
| imidazoles: clotrimazole, miconazole, ketoconazole | all but ketoconazole. only topical |
| polyenes: nystatin, amphotericin B | nystatin topical, ampho B systemic if severe |
| polymixins | extreme toxicity |
| acyclovir | require bioactivation by viral DNA thymidine kinase, binds to nucleic acid polymerase |
| Pyrimidine analogs | zidovudine(thymidine) stavudine, lamivudine (cytosine) |
| Purine analogs | didanosine (adenine) |
| Rifampin | DNA dependent RNA polymerase |
| Metronidazole | reduced only under anaerobic conditions -> free radicals |
| foscarnet | pyrophosphate analog, Herpes, CMV, HIV |
| NNRTI - nevirapine, delavirdine, efavirenz | inhibit reverse transcriptase at other site |
| aminoglycosides | 30S require O2 for uptake, complex with ribosomal protein, misreads. The ONLY bacterialCIDAL protein synth inhibitor |
| Tetracycline | 30S require energy active transport. prevent access of tRNA to mRNA ribosome complex |
| clindamycin | 50S block peptide formation at A site |
| macrolids | 50S block tRNA release |
| Linezolid | 50S inhibit ribosome near peptidyl transferase |
| sulfonamides sulfones | PABA analogs dyhydropteroate synthetase |
| trimethoprim pyrimethamine | DHFR inhibitor |
| isoniazid pyrazinamide | pyridoxine analog for mycolic acid synthesis |
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