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Antifungals

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roshanbagga's version from 2017-08-08 22:15

Section

Question Answer
Flucytosinefluoropyrimidine analog, needs cytosine permease and deaminase - inhibits synthesis of DNA, RNA, proteins - cryptococcus, candida, leishmania, acanthamoebae
Polyenesbind to ergosterol in cell membrane and disrupt
Azoles - Imidazoles (2N Ketoconazole) and Triazoles (3N Fluconazole, Voriconazole)interfere with ergosterol formation - target Lanosterol 14 alpha-demethylase
Echinocandinsblock 1,3 Beta-D-glucan synthetase which makes glucan, needed for cell wall formation
Nikkomycinprevents chitin formation for cell wall
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