Antidiabetic Drugs

zumecohu's version from 2017-02-19 20:32

Section 1

Question Answer
SulfonylreasGlipizide (Glucotrol), Glyburide (Diabeta, Micronase)
SGLT2Dapagliflozin, Canagliflozin, Empagliflozin
Thiazolidinediones (TZD's)Pioglitazone (Actose), Rosigutazone (Avandia)
BiguanidesMetformin (Glucophage)
DDP-4sSitagliptin, Saxagliptin, Alogliptin, Linagliptin
GLP-1 RAExenatide, Liraglutide, Albiglutide, Dulaglutide

Section 2

Question Answer
SE Increases weight, Heart failure, CHF, Bone Fx, LDLs, & MIThiazolidinediones (TZD's)
SE Angioedema, skin reactions, Pancreatitis, URIDDP-4
SE Most common is GI upset, least common is lactic acidosis, may reduce B12Biguanides
SE Increased UTIs & Yeast infections from Increased glycosuriaSGLT2
SE Hypoglycemia and Increased WeightSulfonylreas
SE N/V, Increased risk of Pancreatitis, Injectable training requiredGLP-1 RA

Section 3

Question Answer
Help decrease weight, lower BP, lower CVD events, Cost HIGHSGLT2
No hypoglycemia, decrease weight, increase satiety, lower CVD events, may cause Pancreatitis or Thyroid CA, Cost HIGHGLP-1 RA
Well studied, decrease weight, NO hypoglycemia, Cost LOWBiguanides
Well studied, Increase weight, May cause hypoglycemia, Cost LOWSulfonylreas
No hypoglycemia, Improves HDL/TGs, Cost LOWThiazolidinediones (TZD's)
No hypoglycemia, Weight Neutral, Well tolerated, Cost HIGHDDP-4

Section 4

Question Answer
Thiazolidinediones (TZD's)Contraindicated in Heart Failure or Hepatic dysfunction
SulfonylreasContraindicated with Insulin
BiguanidesContraindicated for CR >1.4/1.5 & GFR <30, Can cause kidney failure and lead to lactic acidosis
GLP-1 RAapproved for use with Basal Insulin, but not prandial insulin, DO NOT use in T1DM, caution with gastroparesis patients