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Antidiabetic drugs

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oeshnoeugo123's version from 2018-03-25 21:18

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Exenatide (Byetta)incretin mimetic, has to be injected 2X day before meals
Liraglutide (Victoza)incretin mimetic, can be injected once a day anytime
Exenatide (Byetta)may cause pancreatitis
Dulaglutide (Trulicity)incretin mimetic injected once a week that increases risk of thyroid cancer
1. Glipizide (Glucotrol)
2. Glyburide (Micronase)
3. Glimeperide
sulfonylureas
Sitagliptin (Januvia)
-suffix "-gliptin"
DPP-4 Inhibitor, taken orally, blocks breakdown of endogenous incretins
Exenatide (Byetta)derived from Gil monster saliva hormone
1. Sulfonylureas
-Glyburide (Micronase)
-Glipizide (Glucotrol)
2. Meglitinides
-Repaglinide (Prandin)
-suffix "-glinide"
lowers blood glucose by stimulating insulin release from the pancreatic beta cells
Metformin (Glucophage)reduces glucose production in the liver and increase the amount of glucose used by muscles and fat
Metformin (Glucophage)most associated with lactic acidosis
Biguanide, alpha-glucosidase inhibitorsNot known to cause hypoglycemia
Metformin (Glucophage)plasma levels not altered by aspirin or NSAIDS
Acarbose (Precose)
-an alpha-glucosidase INHIBITOR
slows down the digestion of sugars and starches thus leading to lower blood glucose levels after eating
Thiazolidinediones
1. Pioglitazone (Actos)
2. Rosiglitazone (Avandia)
lowers blood glucose by improving target cell response to insulin, without increasing pancreatic insulin secretion
Repaglinide (Prandin)stimulates the pancreas to make more insulin, but at a different site than sulfonylureas
Invokana (canagliflozin)
-suffix "-flozin"
SGLT-2 inhibitor that reduces glucose reabsorption in kidney thereby increasing insulin sensitivity of target tissue
Thiazolidinedione
-Troglitazone = drug removed from market
this class has been associated with liver toxicity leading to removal of one drug of this class from the marketplace
repaglinidine (Prandin)plasma levels may be increased by erythromycin
-meglitinides - repaglinide (Prandin
-sulfonylureases
NSAIDS may potentiate its actions
Invokana (canagliflozin)
-suffix "-flozin"
decreases renal reabsorption of glucose
repaglinide (Prandin)3A4 substrate, metabolism inhibited by macrolides
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