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Antidiabetic Drugs

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jdunca17's version from 2016-11-28 15:20

Section

Section 1
Question Answer
SulfonylreasGlipizide (Glucotrol), Glyburide (Diabeta, Micronase)
Megletinide AnaloguesRepaglinide (Prandin), Nateglinide (Starlix)
Thiazolidinediones (TZD's)Pioglitazone (Actose), Rosigutazone (Avandia)
BiguanidesMetformin (Glucophage)
Alpha Glucosidase InhibitorsAcarbose (Precose), Miglitol (Glyset)
Gliptinssitagliptin (Januvia)
memorize

Section 2

Question Answer
reduce insulin resistance of tissues and insulin must be availableThiazolidinediones (TZD's)
Stimulates to release of insulin from the pancreas; postprandial hyperglycemiaMegletinide Analogues
reduce the production of glucose by the liver; glucogenesisBiguanides
delay carb absorption in the GI tractAlpha Glucosidase Inhibitors
stimulates the pancreas to release insulin based on BG levelsSulfonylreas
augments increatin by inhibiting enzyme that activates itsGliptins
memorize

Section 3

Question Answer
Side effects include flatulence, diarrhea, abdominal discomfortAlpha Glucosidase Inhibitors
1-30 minutes before mealsMegletinide Analogues
decrease glucose production from liver thereby reducing fasting plasma glucose release and improves receptor sensitivity.Biguanides
Stimulate insulin secretion and increase cell receptor sensitivitySulfonylreas
Reduce oral contraceptive effectThiazolidinediones (TZD's)
memorize

Section 4

Question Answer
Thiazolidinediones (TZD's)Side effects can include M.I. and CHF
SulfonylreasInteractions with: Alcohol, Beta blockers, NSAID's, Diuretics, antibiotics etc.
BiguanidesCan cause kidney failure and lead to lactic acidosis
Megletinide AnaloguesRapid absorption/short acting
Alpha Glucosidase InhibitorsDelays absorption of carbohydrates in small intestines
memorize