Antidiabetic Drugs

chazark's version from 2016-04-20 01:25

Section 1

Question Answer
SulfonylreasGlipizide (Glucotrol), Glyburide (Diabeta, Micronase)
Megletinide AnaloguesRepaglinide (Prandin), Nateglinide (Starlix)
Thiazolidinediones (TZD's)Pioglitazone (Actose), Rosigutazone (Avandia)
BiguanidesMetformin (Glucophage)
Alpha Glucosidase InhibitorsAcarbose (Precose), Miglitol (Glyset)

Section 2

Question Answer
Reduce production of glocose from liver and increase insulin sensitivityThiazolidinediones (TZD's)
Triggers Beta cells to release insulin thereby increasing meal related insulinMegletinide Analogues
Hold 48 hours before and after contrast die and surgery (Must swallow whole)Biguanides
Take with first bite of each mealAlpha Glucosidase Inhibitors
Take 30 minutes before meals (Swallow tablet whole)Sulfonylreas

Section 3

Question Answer
Side effects include flatulence, diarrhea, abdominal discomfortAlpha Glucosidase Inhibitors
1-30 minutes before mealsMegletinide Analogues
decrease glucose production from liver thereby reducing fasting plasma glucose release and improves receptor sensitivity.Biguanides
Stimulate insulin secretion and increase cell receptor sensitivitySulfonylreas
Reduce oral contraceptive effectThiazolidinediones (TZD's)

Section 4

Question Answer
Thiazolidinediones (TZD's)Side effects can include M.I. and CHF
SulfonylreasInteractions with: Alcohol, Beta blockers, NSAID's, Diuretics, antibiotics etc.
BiguanidesCan cause kidney failure and lead to lactic acidosis
Megletinide AnaloguesRapid absorption/short acting
Alpha Glucosidase InhibitorsDelays absorption of carbohydrates in small intestines