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Antidepressants

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pivurika's version from 2017-04-23 17:46

Section 1

Question Answer
Imipramine, amitriptyline, desipramine, nortriptyline, clomipramine, doxepin, amoxapineTricyclic antidepressants
Mech: Block reuptake of NE and SerotoninTricyclic antidepressants
Clinical use: major depression, bedwetting, OCD, fibromyalgiaTricyclic antidepressants
BedwettingImipramine
OCDClomipramine
Side effects: Sedation, alpha block effects, atropine like side effectsTricyclic antidepressants
Least sedating and lower seizure thresholdDesipramine
Toxicity: Convulsions, Coma, Cardiotoxicity, respiratory depression, hyperpyrexiaTricyclic antidepressants
NaHCO3 treatment for CV toxicityTricyclic antidepressants
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Section 2

Question Answer
Fluoxetine, paroxetine, sertraline, citalopram, escitalopram, fluvoxamineSSRIs
Mech: Serotonin specific reuptake inhibitorsSSRIs
Clinical use: Depression, OCD, PTSD, PMDD, GAD, panic disorder, bulimia.SSRIs
Toxicity: GI distress, sexual dysfunction, serotonin syndromeSSRIs
Hyperthermia, muscle rigidity, cardiovascular collapse, flushing, diarrhea, seizuresserotonin syndrome
Treatment of Serotonin syndromeCyprophentadine (5HT2 receptor antagonist)
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Section 3

Question Answer
Venlafaxine, duloxetineSNRIs
Mechanism: Inhibit serotonin and NE reuptakeSNRIs
Clinical use: DepressionSNRIs
Also used in generalized anxiety disorderVenlafaxine
Also indicated for diabetic peripheral neuropathyDuloxetine
Toxicity: Increase BP, sedation, nausea, stimulant effectsSNRIs
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Section 4

Question Answer
Phenelzine, Tranylcypromine, isocarboxazin, selegilineMAO inhibitors
Mechanism: Nonselective MAOI, increase level on amine NT (NE, DA, 5HT)MAO inhibitors
Clinical use: Atypical depression, anxiety, hypochondriasisMAO inhibitors
Toxicity: Hypertensive crisis with tyramine ingestion and Beta agonist, CNS stimulationMAO inhibitors
Contraindicated with SSRIs or merperidineMAO inhibitors
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Section 5

Question Answer
Used for smoking cessationBuspirone
Toxicity: stimulant effects (tachycardia, insomnia), headache, seizure in bulimic patientsBuspirone
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Section 6

Question Answer
alpha 2 antagonist ( increase release of NE and serotonin) and potent 5HT2 and 5HT3 receptor antagonistMirtazapine
Toxicity: sedation, increase appetite, weight gain, dry mouth.Mirtazapine
Blocks NE reuptake. Toxicity: sedation, orthostatic hypotensionMaprotiline
Inhibits serotonin reuptake. Use for insomnia. Toxicity: sedation nausea, priapism, postural hypotensionTrazodone
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