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Anticancer drugs

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oeshnoeugo123's version from 2018-03-25 22:34

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Rituximab (Rituxan)A chimeric monoclonal antibody (Mab) targeting the antigen CD-20 on mature B cells. Approved for For Non-Hodgkins Lymphoma, Chronic Lymphocytic Leukemia
etoposidealkaloid derived from mandrake root that inhibits topoisomerase II an enzyme which unwinds DNA in order for replication to take place
methotrexateantifolate antimetabolite type chemotherapeutic agent
tamoxifenselective estrogen receptor antagonist (SERM) useful for treating breast and prostate cancer
bleomycinMay induce pulmonary toxicity in patients administered high concentrations of oxygen during anesthesia
Odansetron5-HT3 receptor antagonist used to reduce nausea and vomiting associated with chemotherapy
cyclophosphamide (Cytoxan)Alkylating agent nitrogen mustard anticancer drug that is also used as a potent immunosuppressive in the control of organ rejection
Bevacizumab (Avastin)monoclonal antibody Angiogenesis inhibitor targets VEGF
cisplatinantineoplastic agent which seems to cause the most severe nausea and vomiting
cyclophosphamide & vincristinethis drug(s) is a 3A4 substrate - therefore, avoid combining with azole antifungal or macrolide antibiotic administration
methotrexaterenal clearance decreased by NSAIDs and penicillins
cisplatin may see thin blue line in gingiva in patients taking this medication
bleomycinantitumor antibiotic that causes DNA scission and fragmentation
Cetuximab (Erbitux)Chimeric MAb directed against an epidermal growth factor receptor (EGFR)
Trastuzumab (Herceptin)Human Mab against human EGFR-2 that is approved as therapy for HER2 overexpressing breast cancer
vincristinevinca plant alkaloid that prevents microtubule formation
Doxorucibin (Adriamycin)anthracycline antibiotic that interacts with topoisomerase II to induce strand breaks in DNA
Imatinib (Gleevec)small cell type tyrosine kinase inhibitor
-used in treating chronic myelowgenous leukemia (CML)
-signal transduction inhibitor
Interferon, Interleukin-2classed as a biological response modifier because it potentiates host immune response
antimetabolites - methotrexateacts during S phase of cell replication
-antimicrotubular - vincristine, Docetaxol, Taxol
-topoisomerase inhibitors - etoposide
-vinca alkaloids - vincristine
acts during M phase of cell replication
-antibiotics - bleomycin, Adriamycin (Doxorubicin)acts during G2 phase of cell replication
Bevacizumab (Avastin)angiogenesis inhibitor
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