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ANTIBIOTICS

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alapaj's version from 2016-05-19 09:29

Section

Question Answer
VRELinezolid
Strep pyogenespenicilin
Mycobacterium TBIsioniazid & ethambutol & rifampicin & pyrazinamide
Legionella pneumophilaerythromycin
Candida albicansnystatin
Neisseria gonhorreaspectinomycin
MRSAVancomycin
MRSATetracyclines
MRSALinezolid
MRSAClindamycin
MRSADaptomycin
MRSACephalosporins (5th)
Escherichia coliampicillin
Staph aureusVancomycin
Mycoplasma pneumoniaeMacrolides (Erythromycin)
Pseudomonas aeruginosaAmikacin / piperacillin
Bacteroides fragilisMetronidazole
Clostridium dificileMetronidazole
Chlamydia trochomatisErythromycin
VREDaptomycin
DermatophytesGriseofulvin
Treponema pallidumpenicillin, erythromycin
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mechanisms of resistance

Types of resistanceMechanism of resistanceBacteria in which it occursClinical interpretation
ESBLβ lactamases (cephalosporinases)Escherichia coliResistance to all penicillins, monobactams and cephalosporins
MRSAPBP2a / MecA gene, MethicilinStaphylococcus aureusResistance to all β lactams and β lactams/ β lactamase inhibitor
PRSPPBPs(Pbp1a, 2b and 2x)Streptococcus pneumoniaResistance to all penicillins
KPCCarbapenemasesKlebsiella PneumoniaeResistance to β lactams
HLARAminoglycoside modifying enzymeEnterococciResistance to aminoglycosides
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antibiotics and their subgroups

Question Answer
Aminoglycosidesamikacin
Tetracyclinesdoxycycline
Lincosamidesclindamycin
MacrolidesErythromycin
Oxazolidinoneslinezolid
Streptograminssynercid
Fluoroquinolones ciprofloxacin
CarbapenemsImipenem
Streptograminsvirginiamycin
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antibiotics action

Mechanism of inhibitionantibiotic
Cell wallβ lactams
Cell wallglycopeptides
Protein synthesis (30S)Aminoglycosides
Protein synthesis (50S)oxazolidinones
Nucleic acid (DNA)Quinolones
Nucleic acid (RNA)Rifamycin
Folic acid synthesissulfonamides
Folic acid synthesisthrimetoprim
Cell membranePolymyxins (B/E)
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cephalosporins

generationsubtypesactive against
1st generationcephazolin, cephalexingram (+) cocci, enterobacteriaceae - PEK (Proteus, E. coli, Klebsiella)
2nd generationcefoxitin, cefaclorenterobacteriaceae, Haemophilus, Bacteroides
3rd generationceftizidime, cefotaximeHaNyS - H. influenzae, N. meningitidis, S. pneumoniae
4th generationcefepimeAll enterobacteriaceae, Pseudomonas aeruginosa
5th generationcefroralineMRSA, PRSP, E. faecalis
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