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Anti-viral Drugs

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turlough's version from 2017-10-30 00:15

Section 1

Question Answer
Drug class of Aciclovir Viral DNA Polymerase inhibitor
Aciclovir indicationsTreatment, prophylaxis and suppression of herpes simplex infections. Treatment of Varicella and Herpes Zoster.
Aciclovir Mechanism Aciclovir is a nucleoside analogue. It is selectively phosphorylated by viral thymidine kinase enzymes. This results in inhibition of viral DNA polymerase as well as termination of DNA chain growth.
Reason for adjusting the dose of aciclovir Renal impairment. Adjust the dosing intervals according to creatinine clearance.
Does food affect aciclovir absorption? No
Aciclovir contra-indicationsHypersensitivity to aciclovir or valaciclovir
6 common side effects of aciclovir Malaise, headache, dizziness, nausea, vomiting and diarrhoea.
Aciclovir brand name Zovirax. Available as
5 formulations of Aciclovir Dispersible tablets, cream, oral suspension, eye ointment and solution for infusion.
2 counselling points for patients taking aciclovir. Symptoms should improve within 2-3 days but it is essential that you finish the course. Drink plenty of fluids while on aciclovir.
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Section 2

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