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Anti Psychotics aka neuroleptics

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mckel67's version from 2016-05-08 17:56

Section 1

Question Answer
Classical antipsychoticsFluphenazine, haloperidol, chlorpromazine, thioridazine
Atypical antipsychoticsClozapine, risperidone, paliperiodne, olanzapine, quetiapine, ziprasidone, aripiprazole
Fluphenazineclassical
haloperiodolclassical
Quetiapineatypical
clozapineatypical
aripiprazoleatypical
thioridazineclassical
risperidoneatypical
haloperidolclassical
ziprasidoneatypical
olanzapineatypical
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Section 2

Question Answer
classical mechanism of actionblocks d2 in mesolimbic pathway
atypical mechanism of actionhigher affinity for other receptors than D2
Clozapine MOAD1, D4, 5HT2, M and alpha adrenergic in addition to D2
Risperidone MOA5HT2 greater than D2
memorize

Section 3

Question Answer
TX for AE: Parkinsonismbenztropine, trihexyphenidyl, amantadine, diphenhydramine *NEVER LEVODOPA*
TX for AE: Akathisiadecrease dose or change; clonazepam or propranolol may also be added
TX for AE: Tardive DyskenesiaMay be irreversible. Discontinue or decrease dosage. Eliminate all central anti-cholinergics (TCAs). diazepam may be helpful
Can cause seizuresChlorpromazine and clozapine "the C's cause CCCCsures"
AE of clozapineagranulocytosis
Causes weight gainclozapine and olanzapine no ziprasidone
CardiotoxicityThiordazine (QT, T-wave, Vtach), Ziprasidone (QT)
OcularChlorpromazine causes corneal and lens despots; thioridazine causes retinal issues
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