Create
Learn
Share

Anginal Drugs

rename
crbvi's version from 2017-04-10 10:54

MOA

Question Answer
propololdecrease HR, contractility, BP (decrease O2 demand)
nitratesdecrease preload, increase coronary artery perfusion, increase cGMP
Ca channel blockersdecrease afterload(arterio-dilate) increase coronary artery perfusion, slow HR
BisprololB1 selective
metaprololB1 selective
isoboride dinitratevenodilator then metabolized to 5-mononitrate
diltiazemmostly cardiac effects
verapamilmostly cardiac effects
DHPmostly peripheral effects
nimodipinecerebral Ca channel blocker, prevents vasospasm after cerebral hemorrhage
amlodipinelong lasting Ca channel blocker
tPathrombolytic, use only in STEMI, converts plasminogen to plasmin
myosin reaction to phophorylationactivation
cilostizolPDE inhibitor, vasodilator
memorize

side effects

Question Answer
rapid stoppage can be awfulB-blocker
bronchospasmB-blocker
fatigue, ED, nightmaresB-blocker
increase EDV, increase ejection timeB-blocker
bad HAnitrate
reflex tachycardianitrates
MI on rapid injectionnifedipine
reflex tachycardianitrate
syncope, orthostatic hypotensionnitrate
edema, constipation, dizzyniessCa channel blocker
absolute contraindication for B-blockerAV block, unstable HF, cardiogenic shock, severe bronchospasm, severe bradycardia
relative contraindications for B-blockerasthma, diabetes
bronchiole constriction and low blood sugarhigh dose of bisprolol or metaprolol
memorize

Pharmacokinetics

Question Answer
daily use half lifebisprolol (8-12 hrs)
CYP2D6metaprolol
long half lifeamlodipine
do not use with sildenofilnitrates(within 6 hours)
avoid 1st pass with nitratesublingual
glutathione-5converts nitrate to NO
tolerance fixed by adding SHnitrates
serum protein binding 30 %bisprolol
memorize

Section 4