Angina, MI & CHF

phrm1013's version from 2016-05-11 19:27


This page will help you learn a few things about some cardiac drugs and conditions.


Question Answer
Unstable anginaArtery is almost completely occluded - symptoms NOT relived by rest or nitroglycerin
Stable anginaExertional angina – symptoms relieved by rest or nitroglycerin
Prinzmetal angina variant angina – cause by vasospasms
Classes of drugs used to treat anginanitrates, b-blockers, calcium channel blockers
MOA of nitratesProdrug of Nitric Oxide  relaxation of smooth muscles  reduces preload and afterload
Storage of Nitrostat®SL tablets, store in original bottle, sensitive to light and moisture
Priming of Nitrolingual®3 sprays for the first time, 1 spray if not used in 14 days
Wait time between nitroglycerin doses5 minutes
Reason for nitrate-free intervalstolerance develops rapidly to long-acting nitrates
Significant nitrate drug interactionphosphodiesterase-5 inhibitors (sildenafil, tadalafil, vardenafil)
Complications of STEMIDeath, heart failure, arrhythmias, reinfarction


Question Answer
Dosage form of Nitrol®topical ointment
Dosage form of Minitran®transdermal patch
Dosage form(s) of ISDN®immediate release and controlled release tablets
Cardiac cocktail for post-STEMIASA + B-Blocker + Statin + ACEI + nitroglycerin
Body compensation in heart failurecardiac hypertrophy, sympathetic activation, RAAS activation
Class II heart failureSymptoms with ordinary activity
Diuretic class used in heart failureloop
Drug added in for refractory edema in heart failuremetolazone (Zaroxolyn®)
Digoxin MOAincreases force of contractions and slows rate of contraction by affecting Na+
Antidote for digoxinDigibind Digifab®
Digoxin signs of toxicityvomiting, visual disturbances (halos), irregular heart rate
Amiodarone adverse effectsdizziness, tremors, ataxia, pulmonary fibrosis, bradycardia, blue-grey skin, corneal deposits