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Anemia Drugs

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valesoje's version from 2017-02-22 14:32

Section 1

Question Answer
Hydroxurea Recurrent Sickle Cell Anemia (PO)
ferrous sulfateiron deficiency, microcytic anemia (PO)
ferrous gluconateiron deficiency, microcytic anemia (PO)
ferrous fumarateiron deficiency, microcytic anemia (PO)
iron dextranpt with chronic kidney disease w dialysis who can't take PO/ferrous groupa (IM/IV)
deferoxamineacute iron poisoning (hemochromatosis) - aplastic anemia (IM/IV)
cyanobalaminVitamin b12 deficiency, pernicious/macro anemia (IM/IV)
hydroxocobalaminVitamin b12 deficiency, pernicious/macro anemia (IM/IV)
folacinfolic acid deficiency, macrocytic anemia/spina bifida (PO)
epoetin alfaanemia w crhonic renal fail, HIV, cancer (IV/sq)
darbepoetin alfa (long acting)anemia w crhonic renal fail, HIV, cancer (IV/sq)
filgastrim (G-CSF)neutropenia (Sq) - prevent neutropenia of pt in chemo
sargramostim (GM-CSF)neutropenia (sq) - prevent neutropenia of pt in chemo
oprelvekin (IL-11)secondary prevent of thrombocytopenia in pt in chemo (sq)
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Section 2

Question Answer
hydroxureaanticancer; inhibits ribonucleotide reductase > dcrease dNTPS in S phase > increase HbF
ferrous sulfateiron supplement
ferrous gluconateiron supplement
ferrous fumarateiron supplement
iron dextran iron supplement
deferoxaminechelates excess iron; reduces toxicity of excess of iron
cyanobalamindecrease in homocysteine and recycles folic acid for dUMP to dTMP
hdroxycobalamindecrease in homocysteine and recycles folic acid for dUMP to dTMP
folacincoofactor supplement for adequate supplies for DNA synthesis
epoetin alfastimulates erythrocyte proliferation and differentation, allows reticulocyte release from bone marrow
darbepoetin alfastimulates erythrocyte proliferation and differentation, allows reticulocyte release from bone marrow
filgastrimstim G-CSF receptors on neutrophils and progenitors to icnrease prolif andd phagocytic activity and extend survival
sargramostimstimulate GM-CSF receptors to stim prolif and diff of G-CFU, erythroid, ad megakaryocye progenitors
oprelvekinrecomb IL-11 stim growth of lymphoid and myeloid cells includ megakaryocyte progenitors. increase number of platelets and neutrophils
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Section 3

Question Answer
hydroxyurea adverse effectshematopoeitic depression, GI, tetratogenic
ferrous sulfate adverse effectsconstripation, diarrhea, nausea, GI, cramps toxic: necrotizing GI, ab pain, bloody diarrhea, lethargy, dyspnea, shock,iron excess cause heart liver and pacnreas to fail
ferrous gluconate adverse effectsconstripation, diarrhea, nausea, GI, cramps toxic: necrotizing GI, ab pain, bloody diarrhea, lethargy, dyspnea, shock,iron excess cause heart liver and pacnreas to fail
ferrous fumarate adverse effectsconstripation, diarrhea, nausea, GI, cramps toxic: necrotizing GI, ab pain, bloody diarrhea, lethargy, dyspnea, shock,iron excess cause heart liver and pacnreas to fail
iron dextran adverse effets constripation, diarrhea, nausea, GI, cramps toxic: necrotizing GI, ab pain, bloody diarrhea, lethargy, dyspnea, shock,iron excess cause heart liver and pacnreas to fail also causes hypersenstiitivty rxns, light head, fever,vomit, flush, and pain
deferoxamine toxicityrapid IV administration = hypotension, neutrotox, increase to infections
cyanobalamin adverse fxnone
hydroxocobalamin adverse fxnone
folacin adverse fxnonee
epoetin alfa toxicityhypertension and thrombosis - rarely: red cell aplasia
darbepoetin alfa toxicitiyhypertension and thrombosis - rare: red cell aplasia
filgastrim toxicitybone pain, rare: spleen rupture
sargramostim adverse fxfever, arthralgia, myalgia, capilarry leak syndrome
oprelvekin toxicityfatigue, headache, dizzy, anemia, edema, arrhytmia
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