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Alternatives- PHARM 2

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lunalovegood's version from 2016-09-19 21:53

Section 1

Question Answer
Cefuroximepenetrates CNF (meningitis - Cephotaxime)
Mod for antibacterialR1
Mod for metabolism & kineticsR2
Cephalexin 1
Cefamandole, Cefaclor, Lorbacef2
Cefotaxime3
Cefepime4
Gram +1
No activity enterococci1
Beta lactamase sensitive1
Pseudomonas3, 4
Penicillin resistant strep pneumoniae3, 4
MRSA, enterococci4
Like always given IV4 (3 is regularly)
Cross-over reaction of penicillin allergy ___ %20%
Maculopapular rash, increased liver fxn, stop hemostasis, alcohol interolancecephalosporin adverse rxns
Cephalosporins excreted by...kidney
memorize

Section 2

Question Answer
Highly specific PBP2carbapenems
Imipenem, Meropenemcarbapenems
Wide spectrum, Beta lactamase resistant, cross rxn penicillin, MRSAcarbapenems
No thiazolidine ringMonobactam
AztreonamMonobactam
Seems uselessMonobactams (limited to aerobic gram negative, Beta lactamase sensitive, only injection, but at least it lack cross rxn penicillin)
Erythromycin, Clarithromycin, AzithromycinMacrolides
50SMacrolides & Clindamycin
30STetracycline
Microsomal enzyme inhibitorErythromycin & Clarithromycin
Macrolide with less GI problemsClarithromycin
Liver-bile-urine to excreteErythromycin
Liver & or Kidneys to excreteClarithromycin
Liver excreteAzithromycin
OsteomyelitisClindamycin, Fluoroquinolones
Inhibits carboxypeptidaseVancomycin
Very effective through IV, oral = poor absorptionVancomycin
Protozoal infectionMetronidazole
ANUGMetronidazole
Disulfuram like action when taken with alcohol (vomit)Metronidazole (Acetylaldehyde)
Metal tasteMetronidazole
Nitro group gets reduced to metabolites that damage DNAMetronidazole
Increased CNS toxicity with Theophyine or NSAIDsFluoroquinolones
Adverse reactions for heart problem patientsFluoroquinolones
memorize